Diabetic neuropathy is the most common complication of diabetes and according to World Health Organization (WHO) almost 50% of diabetes affected patients have same degree of neuropathy [1]. In terms of health care costs, diabetic peripheral neuropathy has a high post-diagnosis economic impact being associated with a 20% increase in the number of patients visiting hospitals and a 46% increase in...

Although over the years the considerable breakthroughs made in our understanding of diabetic neuropathy has come from both neurologists and diabetologists, in recent times (in the UK) it is diabetologists that have assumed the main clinical role in diagnosing and managing the most common neuropathy in the western world. It may therefore be that referral of patients with diabetic neuropathy from...

The quality of life (QOL) of 79 people with type 1 and type 2 diabetes and 37 non-diabetic controls was assessed using the Nottingham Health Profile (NHP). The NHP consists of six domains assessing energy, sleep, pain, physical mobility, emotional reactions and social isolation. Symptomatic diabetic neuropathy was present in 41 of the patients. The neuropathy patients had significantly higher s...

  Abstract  Introduction: Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. This study was designed to investigate the effect of Nigella sativum (NS) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (STZ)-induced diabetic rats.  Methods: For this...

  Abstract  Introduction: Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. This study was designed to investigate the effect of Trigonella foenum-graecum (TFG) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (STZ)-induced diabetic rats.  Method...

OBJECTIVE To investigate and compare the influence of a previous history of foot ulcers on plantar pressure variables during gait of patients with diabetic neuropathy. INTRODUCTION Foot ulcers may be an indicator of worsening diabetic neuropathy. However, the behavior of plantar pressure patterns over time and during the progression of neuropathy, especially in patients who have a clinical hi...

Objective: Alteration in the basement membrane proteins maybe associated with diabetic neuropathy. Fibronectin is one of the most important components of peripheral nerves basement membrane. In this study we investigated the effects of insulin administration on prevention of alteration in fibronectin contents of sciatic nerve in diabetic rats. Materials and Methods: Twenty-four wistar rats wer...

Several studies indicate an association between obstructive sleep apnea syndrome (OSAS) and diabetic autonomic neuropathy (DAN). Observed frequency of OSAS in diabetic patients with DAN varies between 26% and 30%. Excessive daytime sleepiness is one of the major clinical symptoms of sleep disordered breathing. Diabetics with autonomic neuropathy might have abnormal control of respiration during...

OBJECTIVE To illustrate the prevalence of different types of neuropathy in diabetic patients with diabetic foot. METHODS This is a retrospective study of 229 diabetic foot patients treated at Princess Haya Hospital Hyperbaric Department, Aqaba, Jordan from January 1997 to January 2008, who were found to have different types of neuropathy. Neuropathy diagnosis was reached through investigating...