PURPOSE Diabetic macular edema can be refractory to multiple treatment modalities. Although there have been anecdotal reports of ranibizumab showing efficacy when other modalities provided limited benefit, little has been published on treatment for refractory diabetic macular edema. This study sought to investigate this observation further. METHODS Retrospective chart review. RESULTS Thirty...

BACKGROUND The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema. METHODS This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to ...

purpose : central retinal vein occlusion (crvo) is the most common vascular event in the eye after diabetic retinopathy. this study was conducted to evaluate the effect of intravitreal triamcinolone (ivt) on acute crvo. materials & methods : in a randomized sham-controlled clinical trial, 27 eyes with recent onset (less than 2 months) crvo were randomly assigned to two groups. the treatment gro...

PURPOSE The outcome of vitrectomy combined with phacoemulsification and intraocular lens implantation (PEA+IOL) for diabetic macular edema was evaluated. METHODS Included in this study were 31 patients (42 eyes) with clinically significant diabetic macular edema, in whom posterior vitreous detachment was not observed. Pars plana vitrectomy combined with PEA+IOL was performed on 15 eyes. Sixte...

A 59-year-old patient with bilateral worsening diabetic macular edema received intravitreal injection of aflibercept (Eylea; Regeneron, Tarrytown, NY) to the left eye only. On 1-month follow-up, there was noted bilateral improvement of visual acuity and diabetic macular edema on spectral-domain optical coherence tomography imaging, reflecting bilateral effect of unilateral treatment with aflibe...

PURPOSE The purpose of this study was to compare high-resolution stereoscopic digital photography to contact lens biomicroscopy (CLBM) for the diagnosis of clinically significant macular edema. STUDY DESIGN Comparative, prospective, observational case series. PARTICIPANTS One hundred twenty diabetic patients. METHODS Patients underwent clinical retinal examination with CLBM by a retinal s...

A 60-year-old man with neovascular glaucoma due to diabetic retinopathy received an intravitreal injection of 1.25 mg bevacizumab (IVB) followed by extensive panretinal photocoagulation in the right eye. The anterior segment neovascularization regressed within 10 days after IVB. One and a half months later, the patient underwent gastrectomy for stage IIIb gastric cancer. Two months later, he wa...

For eyes with diabetic retinopathy which require vitreous surgery and pan-retinal photocoagulation (PRP), pre-treatment of PRP before vitreous surgery reduce the activity of diabetic retinopathy, however sometimes cause macular edema leading to visual disturbance. Some cytokines in the vitreous increase in eyes with diabetic macular edema, thus the relationship between PRP and vitreous cytokine...

The prevalence of diabetes is growing at epidemic rates in the USA. Diabetic retinopathy develops in a large proportion of patients and is a leading cause of blindness worldwide. Systemic management of diabetic retinopathy has included glycemic, hypertension, and lipid control. Local ophthalmic treatment in the form of focal/grid or panretinal laser photocoagulation has been shown to prevent vi...

PURPOSE To investigate macular thickness and visual acuity changes after 1 intravitreal injection of 0.5-mg ranibizumab during phacoemulsification cataract surgery in eyes with diabetic macular edema refractory to laser treatment. METHODS Eleven eyes of 11 patients with diabetic macular edema refractory to modified Early Treatment Diabetic Retinopathy Study laser therapy received intravitreal...