disease-associated genetic variants in the complement alternative pathway. Biochim Biophys Acta. 2011;1812:12–22. 5. George JN. Systemic malignancies as a cause of unexpected microangiopathic hemolytic anemia and thrombocytopenia. Oncology (Williston Park). 2011;25:908–14. 6. Campistol JM, Arias M, Ariceta G, Blasco M, Espinosa M, Grinyó JM, et al. An update for atypical haemolytic uraemic synd...

Block factor methods o¤er an attractive approach to forecasting with many predictors. These extract the information in these predictors into factors re‡ecting di¤erent blocks of variables (e.g. a price block, a housing block, a …nancial block, etc.). However, a forecasting model which simply includes all blocks as predictors risks being over-parameterized. Thus, it is desirable to use a methodo...

Combined Immunodeficiencies, Disorders Affecting B Lymphocytes, The Role of the Thymus, and Other States Associated with Primary Immunodeficiency. The strongest areas are the up-to-date authoritative reviews of immunoglobulin therapy and transplant immunoreconstitution. What are the weaknesses? For the non-immunologist, there is the lack of a single section on basic immunology. Much of what you...

Manoj N. Obeyesekere, George J. Klein, Simon Modi, Peter Leong-Sit, Lorne J. Gula, Raymond Tachycardia Syndrome, Long-QT Syndrome, and Catecholaminergic Polymorphic Ventricular How to Perform and Interpret Provocative Testing for the Diagnosis of Brugada Print ISSN: 1941-3149. Online ISSN: 1941-3084 Copyright © 2011 American Heart Association, Inc. All rights reserved. Avenue, Dallas, TX 75231 ...

It is now becoming generally noted that many diseases of hitherto unknown aetiology are due to inborn errors of metabolism in the sense in which Garrod (1923) used this term. Although these diseases cover the whole of medicine it has been particularly gratifying to note that mental disease, especially mental deficiency which currently is responsible for one of our main medical problems, has bee...

B- and T-cell populations in 32 patients with different forms of primary immunodeficiency disease were studied. The B-cells in peripheral blood were investigated with respect to surface immunoglobulins by means of immunofluorescence. The T-cell function was studied utilizing quantitation of proliferative response to phytochemagglutinin (PHA)(1) and delayed allergy to various antigens. In 10 pat...

A case of Di Guglielmo's syndrome passed through the three stages of chronic erythromyelosis, erythroleukemia and acute myeloid leukemia (AML). According to the FAB classification the subsequent stages of this syndrome were refractory anemia (RA), RA with excess of blasts (RAEB), AML-M6, AML-M2 and undifferentiated AML-MO as the end-stage disease. Light- and electronmicroscopice findings on per...

Two patients with chronic myelocytic leukemia who developed an erythroblastic rather than a myeloblastic phase were studied with respect to whether or not the megaloblastic erythropoiesis was subject to normal control mechanisms. After transfusion, no significant reduction was observed in the percentage of nucleated erythroid precursors or of proerythroblasts in marrow or in blood reticulocytes...