OBJECTIVE To evaluate the role of dexamethasone as adjunctive therapy in adult acute bacterial meningitis (ABM) in two groups of patients treated with antibiotics alone or a combination of antibiotics and dexamethasone. DESIGN Systematic sampling interventional open cohort study. SETTING Department of Medicine (Medical Unit II), Jinnah Postgraduate Medical Centre, Karachi. PATIENTS Sixty ...

Background: Dyslipidemia constitutes a serious public health concern globally. It has been established that excessive fructose intake results in dyslipidemia; however, whether dexamethasone aggravates or alleviates fructose-induced dyslipidemia is unknown. Thus, we examined the effects of dexamethasone on dyslipidemia and hyperuricemia in high fructose-taking Wister rats. Methods: Twenty male...

INTRODUCTION Neurosurgeons are familiar with chronic subdural haematoma (CSH), a well-known clinical entity, which is usually treated by some modality of trepanation. Despite the excellent outcomes obtained by surgery, complications may occur, some of which may be potentially severe or fatal. Furthermore, up to 25% recurrence rate is reported. The authors present a novel approach to the managem...

BACKGROUND Epidural steroid injections are commonly used in managing radicular pain. Most complications related to epidural injections are minor and self-limited. Flushing is considered as one such minor side effect. Flushing has been studied using various steroid preparations including methylprednisone, triamcinolone, and betamethasone but its frequency has never been studied using dexamethaso...

Aims: Postoperative shivering is unpleasant and annoying for the patient, occurring in up to 65% of cases undergoing general anesthesia. Various mechanisms were suggested postoperative shivering. Shivering after anesthesia can cause complications, such as cardiovascular conditions, bleeding, infection. This study compared effects dexamethasone, pethidine, ketamine on prevention Methods & Ma...

to investigate the safety profile and benefits of a short-term simultaneous treat-ment combining two drugs: an intravitreal implant of dexamethasone with an intravitreal in-jection of bevacizumab in patients with macular edema, this study was performed. this was a retrospective, non-randomized, open-label case series study.  patients were treat-ed between april 2014 and july 2015 and were diagn...