The existing data from research using rodent models have implicated some drugs as being toxic to the developing brain, even causing cognitive deficits in later life. However, there are no data providing evidence that the clinical use of these drugs is associated with signs of developmental neurotoxicity. This Editorial focuses on how use of the developing nonhuman primate, when combined with bi...

1 The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. 2 ABSTRACT Planar halogenated aromatic hydrocarbons (pHAH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon receptor (AHR) and are potent inducers of cytochrome P4501A (CYP1A). It is wide...

Developmental toxicity caused by exposure to a mixture of environmental pollutants has become a major health concern. Human-made chemicals, including xenoestrogens, pesticides and heavy metals, as well as unhealthy lifestyle behaviours, mainly tobacco smoking, alcohol consumption and medical drug abuse, are major factors that adversely influence prenatal development and increase susceptibility ...