Amyloids are highly organized protein aggregates that are associated with both neurodegenerative diseases such as Alzheimer disease and benign functions like skin pigmentation. Amyloids self-polymerize in a nucleation-dependent manner by recruiting their soluble protein/peptide counterpart and are stable against harsh physical, chemical, and biochemical conditions. These extraordinary propertie...

Marcus Poggi de Aragão Dep.de Informática Pontif́ıcia Universidade Católica do Rio de Janeiro [email protected] Eduardo Uchoa Dep. Eng. de Produção Universidade Federal Fluminense [email protected] January 15th, 2005 The Capacitated Vehicle Routing Problem (CVRP) is the most basic variant of a vehicle routing problem: homogeneous fleet, single depot, only deliveries, no time-windows, and ...

This article presents a mathematical model of the risk failures, depending on operating parameters, locomotive diesel engines. The purpose this study is to determine failures engines in maintenance. theory probability and logic reliability are used theoretical study. innovations main works first approaches calculating by hourly fuel consumption, which, under operational conditions, allows for e...

To overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure resulting from multidrug resistance (MDR) and minimize adverse effects of chemotherapy agents, a novel chemotherapy formulation of magnetic nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin (DNR/BrTet-MNPs) was developed, and its effect on MDR leukemic cells was expl...

In the present study, different in situ hydrogel formulations of docetaxel (DTX) based on biocompatible polymers such as Hyaluronic Acid (HA), poloxamer-407, chitosan and gellan gum were formulated to increase its therapeutic efficacy reduce toxicity. DTX was loaded nanovesicles (20 mg/mL equivalent commercial strength) further incorporated into bases possess a dual rationale protection against...

occurrence of natural disaster inflicts irreparable injuries and symptoms on humans. in such conditions, affected people are waiting for medical services and relief commodities. thus, quick reaction of medical services and relief commodities supply play important roles in improving natural disaster management. in this paper, a multi-objective non-linear credibility-based fuzzy mathematical prog...

A space transportation infrastructure is described that utilizes propellant depots to support all foreseeable missions in the Earth-Moon vicinity and deep space out to Mars. The infrastructure utilizes current expendable launch vehicles such as the Delta IV Heavy, Atlas V, and Falcon 9, for all crew, cargo, and propellant launches to orbit. Propellant launches are made to a Low-Earth-Orbit (LEO...

Since the Vehicle Routing Problem (VRP) was introduced by Dantzig and Ramser, it became one of the most studied problems in Combinatorial Optimization. Different solution approaches were proposed over the past decades to solve the VRP and its variants. In this thesis, we discuss about two VRP variants, resulting from the integration of VRPs with distribution problems. The first problem takes pl...