Nucleic acid-based therapy is a growing field of drug delivery research. Although ultrasound has been suggested to enhance transfection decades ago, it took a combination of ultrasound with nucleic acid carrier systems (microbubbles, liposomes, polyplexes, and viral carriers) to achieve reasonable nucleic acid delivery efficacy. Microbubbles serve as foci for local deposition of ultrasound ener...

Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and antisense oligonucleotide (ASO), are powerful gene regulators, which have been demonstrated as promising drug candidates for therapeutic treatments. Nevertheless, poor cellular membrane permeability and serum stability have greatly hindered the applications of nucleic acids in biomedicine. To address these issues...

The incorporation in vivo of compounds labeled with N15 or Cl4 into the purines and pyrimidines of nucleic acid has been repeatedly demonstrated (e.g. (l-3)). W e wish to report observations on the incorporation of radioactive erotic acid in vitro into the pyrimidines of the nucleic acid of rat liver slices. It is believed that this procedure will readily permit the study of precursors of nucle...

Abstract Nucleic acids are one of the most important cellular components. These molecules have been studied both experimentally and theoretically. As all-atom simulations still limited to short time scales, coarse-grain modeling allows study those on a longer scale. Nucleic-Acid united RESidue (NARES-2P) is low-resolution coarse-grained model with two centers interaction per repeating unit. It ...

The nucleic acid content of growing normal and pathological tissues has been a subject of interest in recent years. Several investigators (l-7) have studied nucleic acid changes during embryonic development. It is a well established fact that rapidly growing embryonic tissue has a high concentration of nucleic acid. This was recently extended by Reddy and Cerecedo (S), who observed that gestati...

variations in detection sensitivity and quantification of fetal DNA concentrations were noted among laboratories very familiar with real-time PCR technology (21). Further studies will be needed to clarify this issue in addition to the continued exploration of other strategies for the investigation of complex fetal genetic traits by analysis of maternal plasma. These strategies may include the e...

The more than three decades of research in nucleic acid nanotechnology has led to the thrilling progress rationally designed structures and artificial molecular devices with programmable functions various applications. Nucleic acid–based aggregates feature precise recognition sequence programmability, versatility, as well marked biocompatibility, providing promising candidates for biomedical In...

We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.