Abstract STAT3 is considered an oncogene in multiple human cancers. However, its direct involvement dendritic cell (DC)-mediated antitumor immunity and immune checkpoint blockade (ICB) remains unknown. Here, we found that was constitutively activated DCs restrained DC function the tumor microenvironment (TME). Genetic ablation of resulted enhanced T immunity, thereby slowing down progression be...

Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and ...

Monoclonal antibodies that recognize cell surface molecules have been used deliver antigenic cargo to dendritic cells (DC) for induction of immune responses. The encouraging anti-tumor immunity elicited using this immunization strategy suggests its suitability for clinical trials. This review discusses the complex network of DC, the functional specialization of DC subsets, the immunological out...

Neurons sort out a variety of functional molecules to appropriate subcellular destinations. Telencephalin (TLCN; intercellular adhesion molecule-5) is a cell adhesion molecule specifically localized to somatodendritic membranes in the telencephalic neurons. Here, we established a new in vivo strategy to analyze neuronal sorting mechanisms by ectopic expression of molecules of interest in the ce...

Immunotherapy is an emergent form of cancer therapy that offers new and innovative techniques that work to enhance the body’s natural ability to defend itself against harm. This thesis seeks to explore the efficacy of vaccines that target dendritic cells as one particular form of immunotherapy. Vaccination has the potential to provide antigen (Ag) that is accessible to be processed by dendritic...

Axonal selection of synaptic partners is generally believed to determine wiring specificity in the nervous system. However, we have recently found evidence for specific dendritic targeting in the olfactory system of Drosophila: second order olfactory neurons (Projection Neurons) from the anterodorsal (adPN) and lateral (lPN) lineages send their dendrites to stereotypical, intercalating but non-...