Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM with particle size of 161±1.5 nm and polydispersity index of 0.172±0.01 were produced in <1 hour using a wet milling technology, Dena® DM-100. The crystallinity of the processed ARTM was confirmed using differential scanning calorimetry and powder X-ray d...

BACKGROUND/AIMS Hepatocellular carcinoma (HCC) also known as malignant hepatoma is a most common liver cancer. Doxorubicin (Doxo) is an anti-cancer drug having activity against a wide spectrum of cancer types. Clinical Utility of doxo has been limited due to its poor bioavailability and toxicity to heart and spleen. Furthermore, cancer chemotherapeutics have limited oral absorption. Transferrin...

(paper pages 133-156) zagros active fold-thrust belt lies on the northern margin of the arabian continental crust it is a young fold-thrust mountain belt currently shortening, thickening and uplifting as a result of the collision of the arabian and iranian plates. rethickening of crust during collisional orogenies could have been carried out by reversal of fault motion along the mesozoic normal...

Abstract. Permanasari I, Sulistyaningsih E, Kurniasih B, Indradewa D. 2023. Morphophysiological and yield traits of soybean varieties tolerant intercropping with maize. Biodiversitas 24: 3872-3880. Not all grow optimally when intercropped Previously, we identified seven (i.e., "Demas 1", Dena "Dena 2", "Derap "Devon "Wilis") two "Dega 1" "Mahameru") as intolerant based on selection indices yiel...

Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This "superfruit" is known to possess various pharmacological effects including alleviation of chronic oxidative stress and inflammation. In contrast to a large vo...

The characteristics of near-fault ground motion are investigated considering heterogeneous slip distribution on the fault plane. Areas on the fault plane with large slip in compare with the average slip on the fault are known as asperity. The characteristics of strong ground motions in near-fault area are strongly affected by faulting parameters such as asperity location, maximum slip of asperi...

BACKGROUND The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate the possible role of Wnt signaling in hepato-carcinogenesis. METHODS Ninety rats were included in the study and were divided equally into: Control group, rats which received ...

An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been developed in rat liver using presumed preneoplastic lesions, foci of gamma-glutamyltranspeptidase (GGTase)-positive hepatocytes, as the endpoint. To evaluate the tumor-promoting activity of phenobarbital, rats were administered diethylnitrosamine (DENA), 2.0 mmole/kg, followed by 500 ppm phenobarbital in thei...