OBJECTIVE Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort. METHODS 1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Ass...

This study examined the role of transforming growth factor beta 1 (TGF-beta 1) in monocytic differentiation of hematopoietic cells. TGF-beta 1 and retinoic acid (RA) inhibited HL-60 cell growth in a dose-dependent fashion. Treatment of HL-60 cells with a combination of TGF-beta 1 and a 50% optimal dose of RA (RA + TGF-beta 1) resulted in increased growth suppression compared to the individual t...

InDel (insertion deletion length polymorphism) markers is designed for PCR detection based on the Insertion or of DNA fragments different sizes according to sequence a locus between individuals related species, which more and applied in crop genetic research due its rich polymorphism, operational simplicity reliability results. In this study, Qinyou 88 parents were analyzed through marker, four...

BACKGROUND Members of the ALDH1 protein family, known as retinal dehydrogenases (RALDH), produce retinoic acid (RA), a metabolite of vitamin A, and may also oxidize other lipid aldehydes. Of three related ALDH1 genes, ALDH1A1 is most highly expressed in liver. ALDH1A1 is also rapidly gaining importance as a stem cell marker. We hypothesized that ALDH1A1 may have a broad cellular distribution in...

Background: Long-term treatment of rheumatoid arthritis (RA) with prednisolone (PRED) is associated with bone mineral density (BMD) loss. This study aimed to determine the status of BMD in non-compliant women who used PRED alone for RA. Methods: Non-adherent RA taking < 7.5 mg daily PRED without DMARDs for > 6 months, and RA patients taking methotrexate +PRED (RA control) were compared with ag...

Ra is a native, minimal kernel for the Clouds distributed operating system. Clouds supports persistent virtual spaces, called objects and threads that direct computations through these spaces. Clouds is targeted to run in a compute-server — data-server environment, in which processing is done by threads executing on compute-servers (or workstations) and the objects will permanently residing on ...

The common causes of 18p deletion syndrome are spontaneous errors in the chromosomal structure in the early stages of human embryonic development. In this study, a 29-year-old girl was introduced with the features of deletion of chromosome 18. In addition, GTG banding karyotype revealed that this case had a deletion involving the short arm of chromosome 18. In comparison with the usual phenotyp...

Abstract Background Interleukin-17 (IL-17) is a cytokine that promotes activation of multiple catabolic pathways resulting in cartilage and tissue damage. It has features making it increasingly attractive as biological marker, especially rheumatoid arthritis (RA) osteoarthritis (OA). However, its expression heterogeneous; not all patients’ exhibit high IL-17 levels, level along the disease cour...

(TD)-deletion is a well-known variable phonological process subject to the influence of both external social factors and internal structural constraints, including phonetic environmental and morphosyntactic effects. Its profile of variation has been widely investigated in American English dialects. However, it interacts with another grammatical process -the affixation of the regular Pasttense m...