Liquid protein formulations are prone to form aggregates. The effect of nonionic surfactants such as Polysorbate 20 (PS 20) and n-Dodecyl β-D-maltoside (DDM) on the prevention of aggregation and conformational changes of recombinant human IFNβ-1b (rhIFN β_1b) was explored. Polysorbate has been used in formulations of protein pharmaceuticals. There have been concerns about using PS 20 due to its...

"Dipartimento di Matematica Pura ed Applicata, Universiti di Padova, Via Belzoni 7, 35131 Padova, Italy. tCarnegie Mellon University, Schenley Park, Pittsburgh, PA 15213. ICarnegie Mellon University, Schenley Park, Pittsburgh, PA 15213. §Indian Institute of Management, Bannerghatta rd. 560076 Bangalore, India. 1 Carnegie Mellon University, Schenley Park, Pittsburgh, PA 15213. This work was supp...

Our research is placed in the context of business decision making processes. We look at decision making as at a workflow of (mostly mental) activities directed at choosing one decision alternative. Our goal is to direct the flow of decision activities such that the relevant alternatives are properly evaluated. It is outside our purpose to recommend which alternative should be chosen. Since busi...

In this paper we present an approach for mining decisions. We show that through the use of a Decision Data Model (DDM) we can make explicit the knowledge employed in decision making. We use the DDM to provide insights into the data view of a business decision process. To support our claim we introduce our complete, functional decision mining approach. First, a ‘decisionaware system’ introduces ...

A basic problem in empirical economics involves using data from one domain to make out-of-sample predictions for a different, but related environment. When the choice data are binary, a canonical method for making these types of predictions is the logistic choice model. We investigate if it is possible to improve out-of-sample predictions by changing two aspects of the canonical approach: 1) Us...

The Data Diffusion Machine is a scalable virtual shared memory architecture. A hierarchical network is used to ensure that all data can be located in a time bounded by O(log p), where p is the number of processors. The DDM hierarchy requires a high degree of connectivity between clusters of nodes, which can be provided with point-topoint links. For large machines however the wiring will be comp...

Methodology for the simultaneous solution of ordinary differential equations (ODEs) and associated parametric sensitivity equations using the Decoupled Direct Method (DDM) is presented with respect to its applicability to multiresponse parameter estimation for systems described by nonlinear ordinary differential equations. The DDM is extended to provide second order sensitivity coefficients and...

Deformable mirrors (DMs) are widely used in high-power laser systems to improve the output beam quality. However, under irradiation, heat accumulates on DM mirror surface and results induced distortions (LID), which will degrade wavefront correction performance of DM. In order suppress negative impact LID DM’s performance, we introduce dual magnetic connection (DDM), base connected by two-layer...