Oxidative stress due to excessive of reactive oxygen species (ROS) in the body is commonly associated as one underlying mechanisms ultraviolet radiation (UV)-induced damage skin. Reactive sulphur (RSS) has been implicated with potent antioxidant properties and involves modulating cellular signalling transduction pathway. In this current study, potential involvement RSS alleviating UV-induced Ha...

Schisandrin B (Sch B) is a monomer with anti-cancer and anti-inflammatory effects, which are isolated from the plant Schisandra chinensis (Turcz) Baillon. We investigated anti-gastric cancer (GC) effects of Sch its underlying molecular mechanisms. The Cell Counting Kit-8 assay was used to determine on viability GC normal cell lines. Hoechst/propidium iodide staining flow cytometry were assess a...

Introduction Radiation-induced cardiotoxicity is a major concern following radiation treatment or involuntary exposure. The normal functionality of cardiomyocytes becomes limited, which results in deleterious consequences, including an increase the secretion proinflammatory factors, such as HMGB1, and oxidative stress due to increased production NOX4 ROS. Radiation exposure disruption Bax/Bcl-2...

Myocardial ischemia-reperfusion (MI/R) injury is a common and serious complication following reperfusion treatment for myocardial infarction (MI). Increasing evidence has verified the crucial role of circular RNAs (circRNAs) in MI/R processes. The objective this study was to investigate effects potential regulatory mechanisms circHMGA2 on injury. Hypoxia/reoxygenation (H/R) models were establis...

Chaga mushroom (Inonotus obliquus) has been used for a long time as folk medicine treating multiple diseases in several parts of the world without rendering any undesired toxicity. In this study, I. obliquus polysaccharides (IOP) were extracted and assessed to determine their anti-tumorigenic potential human lung cancer cell lines NCI-H23 A549 using cytotoxicity apoptosis assays. MTT assay reve...

The essential oil from Conyza bonariensis (Asteraceae) aerial parts (CBEO) was extracted by hydrodistillation in a Clevenger-type apparatus and characterized gas chromatography–mass spectrometry. antitumor potential evaluated against human tumor cell lines (melanoma, cervical, colorectal, leukemias), as well non-tumor keratinocyte using the MTT assay. effect of CBEO on production Reactive Oxyge...

Objective(s):  The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin–induced hypertrophy. Results:In present study Endothelin treated car...

Certain factors may affect sperm motility and integrity in a freezing process. Reactive Oxygen Species (ROS) is essential damaging the sperm, as previous study revealed that ROS major cause membrane of spermatozoa. This aimed to understand production its interaction within motility, mitochondrial activity DNA damage cryopreservation process Indonesian Ongole grade bull. A total 40 ejaculated se...

Camptothecin (CPT), an alkaloid, was first discovered from plants and has potent anti-tumor activity. Since then, CPT analogs (namely Irinotecan Topotecan) have been approved by the FDA for cancer treatments. Curcumin, on other hand, is a widely used photosensitizer in photodynamic therapy (PDT) treatment. In our previous work, we reported straightforward strategy to construct drug self-deliver...