The cumulative pharmacokinetic pattern of oxaliplatin, a new diamminecyclohexane platinum derivative, was studied in patients with metastatic colorectal cancer. Oxaliplatin was administered by i. v. infusion (130 mg/m2) over 2 h every 3 weeks, and 5-fluorouracil and leucovorin were administered weekly. A very sensitive method, inductively coupled plasma-mass spectrometry, allowed for the determ...

The purpose of this study is to construct a multivariate input based Hidden Markov model on directional changes detect regime in financial markets. For study, Model with inputs was used. Directional were used historical S&P 500 index returns, additionally, Chicago Board Options Exchange's CBOE Volatility Index along commonly performance indicators as the Model. Change able effectively class...

Erratum: Equation (22) contains an error. It should read 100 ɛ(t, 0 °C) = 8.79 × 10 −4 t + 0.805 × 10 −7 t 2. (22) Also, the data presented in Table 12 under the column Day and Sosman Eq. (22) should be evaluated by using the corrected Eq. (22) above.

Four groups of normal rats have been studied to elucidate the effect on the time of birth of four different light regimes applied throughout pregnancy (day 1: beginning of pregnancy). The results showed that the time of parturition (onset of expulsion) depended on the light treatment: the longer the duration of the daily illumination, the longer pregnancy lasted. With a 14 hrs light regime, the...

The objective was to evaluate the effect of equine chorionic gonadotropin (eCG) and hCG post artificial insemination (AI) on fertility of lactating dairy cows. In Experiment 1, cows were either treated with eCG on Day 22 post AI (400 IU; n = 80) or left untreated (n = 84). On Day 29, pregnant cows were either treated with hCG (2500 IU; n = 32) or left untreated (n = 36). Pregnancy and progester...

A case of a 27 year old male with a duplication of part of the long arm of chromosome 22 (22q11.2-q13.1) together with a pericentric inversion of the same chromosome is reported. Particular phenotypic features of note include absence of speech, persistent self-injury, lack of daily living skills, colobomata, and very poor vision. Similarities between this case and other case reports of duplicat...

Nuclear matrix protein 22 (NMP22) is a FDA approved biomarker for bladder cancer. The objective of this study is to develop a simple NMP22 immumosensor (NMP22-IMS) for accurate measurement of NMP22. The NMP22-IMS was constructed with NMP22 antibody immobilized on screen-printed carbon electrodes. The construction procedures and antibody immobilization are simple. Results showed that the NMP22-I...

BACKGROUND Platelets are routinely stored in plasma for 5 days at an average temperature of 22°C. In the present study, the shelf life of random donor platelets was extended by storing for 7 days with and without additive solution at temperatures of 22°C, 18°C, and 16°C. METHODS Random donor platelets were stored in 100% plasma and 20%/80% platelet additive solution. The data were compared us...