P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many drugs, particularly cancer chemotherapeutics. Multidrug resistance (MDR) is caused largely by the efflux of therapeutics out of the tumor cell by Pgp, resulting in reduced efficacy of chemotherapy. SCH66336, a farnesyl transferase inhibitor in development for cancer th...

The patient was diagnosed with ALL at the age of 13 years and commenced on UK 2011 treatment regimen including intrathecal methotrexate, daunorubicin, PEG asparaginase vincristine. She presented eight months after her initial diagnosis.

objective(s):the objective of this study was to investigate the interaction of daunorubicin (dnr) and cardiac myosin (cm) and the changes in mice hearts to exhibit dnr-induced cardiotoxicity . materials and methods:the interaction between dnr and cm was expressed using fluorescence quenching at ph 4.0-9.0 and 15-37 °c. dnr-induced cardiotoxicity was studied using in vivo experiment.  forty grou...

We report a 35 year old male, human immunodeficiency virus (HIV)-infected patient with acquired immune deficiency syndrome (AIDS), who presented with rapidly progressive pulmonary Kaposi's sarcoma. The tumour regressed with treatment with liposomal daunorubicin and remained in partial remission until the patient died 12 months later from complications of HIV infection. Liposomal daunorubicin ma...

Effects of daunorubicin and its new analog, adriamycin, on nucleic acid metabolism were studied in vitro in L1210 mouse leukemia cells with labeled nucleoside precursors and were compared with the established effects of actinomycin D. L1210 ascites tumor cells incubated with daunorubicin under physiological conditions of pH, temperature, and tonicity showed significantly greater inhibition of t...

Daunorubicin has been used in the treatment of six cases of acute lymphoblastic and thirteen cases of acute myeloblastic and mono-myeloblastic leukaemia. Complete remissions were obtained in eight patients, three with acute lymphoblastic leukaemia and five with acute myeloblastic leukaemia. Marrow aplasia makes the drug difficult to administer, but no patients died from this cause, in this seri...

Effects of daunorubicin and its new analog, adriamycin, on nucleic acid metabolism were studied in vitro in L1210 mouse leukemia cells with labeled nucleoside precursors and were compared with the established effects of actinomycin D. L1210 ascites tumor cells incubated with daunorubicin under physiological conditions of pH, temperature, and tonicity showed significantly greater inhibition of t...

Some sterically hindered N-substituted derivatives of daunorubicin are known to be poor substrates for NADH dehydrogenase, NADPH cytochrome P450 reductase and xanthine oxidase. In consequence, poor oxygen radical generation by these compounds is observed. In this study we examined a new family of sugar-N-substituted derivatives of daunorubicin bearing a bulky substituent introduced on the nitro...

In the present paper we show that the overexpression of the NL1Tc protein, encoded by the L1Tc non-LTR retrotransposon from Trypanosoma cruzi, led to a reduction of about 60% of DNA damage caused by daunorubicin treatment. This repair effect is not observed in transfected parasites overexpressing the NL1Tc mutated in the aspartic acid located in the active site of the enzyme. In addition, NL1Tc...

Daunorubicin transport was compared in P388 murine leukemia and in P388/Adramycin (ADR), an anthracycline-resistant subline. We can demonstrate an energy-dependent outward transport system in P388/ADR which limits drug accumulation. Although no calcium requirement for the outward transport process could be shown, several calcium antagonists inhibited outward transport of daunorubicin in P388/AD...