As computers continue to permeate all aspects of our lives, there is a growing tension between the requirements of societal security and individual privacy. Societal security encompasses all ways in which we try to make the world more secure, including transport security, financial security, infrastructure security, etc. A prime mechanism for achieving this security involves collecting quantiti...

lentiviral vectors are among the promising viral based-vectors in gene therapy applications, but the efficiency of their targeting needs to be improved. (strept)avidin-biotin adaptor system is a novel approach to modify the lentiviral envelope for better targeting properties. herein, we describe utilization of this adaptor system by designing a candidate envelope protein-bearing biotin acceptor...

Estimation of support frontiers and boundaries often involves monotone and/or concave edge data smoothing. This estimation problem arises in various unrelated contexts, such as optimal cost and production assessments in econometrics and master curve prediction in the reliability programs of nuclear reactors. Very few constrained estimators of the support boundary of a bivariate distribution hav...

in the process of production, some of the inputs are fixed and cannot easily be changed, such as work hours of workers and hours of administrative or work, these types of inputs are fixed and others are variables. in this paper, by considering some inputs or outputs which are limited, their amounts must be integrated; this concept for integer data is extended. we show the importance of subject ...

Magnetoencephalography (MEG) is increasingly being used to study brain function because of its excellent temporal resolution and its direct association with brain activity at the neuronal level. One possible cause of error in the analysis of MEG data comes from the fact that participants, even MEG-experienced ones, move their head in the MEG system. Head movement can cause source localization e...

A unique feature of the large hepadnavirus envelope protein (L) is its mixed transmembrane topology, resulting from partial posttranslational translocation of the pre-S domain. Using protease protection analysis, we demonstrate for duck hepatitis B virus an essential role for the small envelope protein (S) in this process, providing the first experimental evidence for an S translocation channel...

The dengue virion is surrounded by an envelope of membrane proteins surrounding a lipid bilayer. We have combined the cryoelectron microscopy structures of the membrane proteins (PDB: 3J27) with a lipid bilayer whose composition is based on lipidomics data for insect cell membranes, to obtain a near-atomic resolution computational model of the envelope of the dengue virion. A coarse-grained mol...