Alzheimer's disease (AD) is a devastating neurodegenerative condition with no known cure. While current therapies target late-stage amyloid formation and cholinergic tone, to date, these strategies have proven ineffective at preventing disease progression. The reasons for this may be varied, and could reflect late intervention, or, that earlier pathogenic mechanisms have been overlooked and per...

BACKGROUND The hypermetabolic state induced by acute endotoxemia and malignant hyperthermia (MH) may be indistinguishable. The aims of this study were (1) to investigate the differences between MH and sepsis, (2) to determine whether acute endotoxemia can trigger MH, and (3) to establish the effects of dantrolene in these two disorders. METHODS Three groups of swine were studied. All pigs wer...

BACKGROUND Cerebral vasospasm is a prolonged, occasionally severe, but reversible narrowing of the cerebral arteries that begins 3 to 5 days after the hemorrhage becomes maximal at 14 days. This study is designed to evaluate the effect of dantrolene on the reduction of vasospasm following aneurysmal subarachnoid hemorrhage (SAH). MATERIALS AND METHODS This randomized controlled clinical trial...

The objective – to summarize the current literature data on etiology, pathogenesis, diagnosis and treatment of malignant hyperthermia. search analysis hyperthermia in medical information systems PubMed, Сochrane librarу, Cyberleninka for last 10 years was performed with using keywords: «malignant hyperthermia», «dantrolene», «general anesthesia», «succinylcholine», «inhalation anesthetics». cri...

Mast cells (MCs) are tissue-resident immune cells, which play a pivotal role in skin hypersensitivity reactions. MCs activation via Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) is independent of the classical IgE-mediated pathway, gained much interest recently. Calcium mobilization crucial to mast cell and functional regulation. Ryanodine receptor (RYR) expresses on sarcoplasmic reticulu...

Correspondence To the Editor: Malignant hyperthermia (MH) is a rare but potentially fatal, inherited skeletal muscle disorder that is mostly induced by the ingestion of the depolarizing relaxant, i.e., succinylcholine or volatile anesthetics. Its incidence is reportedly 1/5000 to 1/100,000 in general anesthesia patients, and children seem to be more susceptible than adults. According to MH trea...

A 42-year-old man with neck squamous cell carcinoma underwent awake fiberoptic intubation and tumor resection under general anesthesia. He developed malignant hyperthermia several hours into the surgical procedure. This case highlights hyperthermia’s (MH) variable time course, pathognomonic signs, need for rapid diagnosis treatment. Early recognition treatment led to resolution of MH. Ongoing d...

Kv1.3 is a voltage-gated K(+) channel expressed in insulin-sensitive tissues. We previously showed that gene inactivation or pharmacological inhibition of Kv1.3 channel activity increased peripheral insulin sensitivity independently of body weight by augmenting the amount of GLUT4 at the plasma membrane. In the present study, we further examined the effect Kv1.3 on GLUT4 trafficking and tested ...

Dantrolene is the only drug proven effective for prevention and treatment of malignant hyperthermia (MH). Current dosing recommendations are based on noncompartmental analyses and are largely empiric. They are also divergent, as evidenced by differing recommendations from the Malignant Hyperthermia Association of the United States (MHAUS) and European Sources. We determined the compartmental ph...

(臨床神経 2012;52:261) 平成 23 年 10 月 20 日 拝啓 臨床神経学 2011;51:777-780 に掲載された「ダントロレ ンの有用性が示唆されたけいれん重積発作の 1例」を興味深 く拝読しました.統合失調症の患者が間代性けいれんを呈し, ダントロレンの投与でけいれん発作が消失したことより,ダ ントロレンがけいれん発作に有効な可能性が示唆されたとい う要旨です.本論文の考察では,悪性症候群とけいれん発作の 合併はまれであり,重積発作までいたったものは 4例のみで あること,および,けいれん発作がダントロレンの投与直後か ら消失したことから,悪性症候群の病態の関与は否定的と考 察されています.著者らは当初,筋強剛や著明な発汗,頻拍, CPK高値より,悪性症候群の可能性を考慮して,ダントロレ ンやブロモクリプチンを投与しましたが,最終的に,意識障 害,CPK上昇...