نتایج جستجو برای: damage tolerance limit

تعداد نتایج: 532404  

Journal: :Cancer research 1997
S W Johnson P B Laub J S Beesley R F Ozols T C Hamilton

We have examined a panel of 12 unrelated human ovarian cancer cell lines derived from patients who were either untreated or treated with platinum-based chemotherapy to determine whether a relationship is present between cisplatin sensitivity and: (a) cellular platinum accumulation; (b) glutathione levels; (c) platinum-DNA adduct formation; (d) platinum-DNA adduct removal; and (e) platinum-DNA d...

Journal: :Genetics 2005
Daniel M Sheedy Dora Dimitrova Jessica K Rankin Kirstin L Bass Karen M Lee Claudia Tapia-Alveal Susan H Harvey Johanne M Murray Matthew J O'Connell

The structural maintenance of chromosome (SMC) proteins are key elements in controlling chromosome dynamics. In eukaryotic cells, three essential SMC complexes have been defined: cohesin, condensin, and the Smc5/6 complex. The latter is essential for DNA damage responses; in its absence both repair and checkpoint responses fail. In fission yeast, the UV-C and ionizing radiation (IR) sensitivity...

2014
Reiko Sanokawa-Akakura Elena A. Ostrakhovitch Shin Akakura Scott Goodwin Siamak Tabibzadeh Stefan Strack

We recently demonstrated that cancer cells that recover from damage exhibit increased aerobic glycolysis, however, the molecular mechanism by which cancer cells survive the damage and show increased aerobic glycolysis remains unknown. Here, we demonstrate that diverse cancer cells that survive hypoxic or oxidative damage show rapid cell proliferation, and develop tolerance to damage associated ...

Journal: :Proceedings of the National Academy of Sciences 2003

Ali Shokouhfar Faramarz Ashnaye Ghasemi Seyyed Mohammad Reza Khalili

In this paper, the response of hybrid composite laminate plate reinforced by the smart wires (shape memory or the SMA wires) subjected to low velocity impact is studied. The smart wires are embedded within the layers of the composite laminate. The effect of the smart wires on contact force history, and deflection of these structures is investigated. The first-order shear deformation theory as w...

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