Objective The variety of disease phenotypes among patients with SLE challenges the identification of new biomarkers reflecting disease activity and/or organ damage. Osteopontin (OPN) is an extracellular matrix protein with immunomodulating properties. Although raised levels have been reported, the pathogenic implications and clinical utility of OPN as a biomarker in SLE are far from clear. Thus...

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great volume of knowledge in the field has been accumulated. Here we attempted to organize the evidence "for" and "against" the hypothesized causal role of DNA damage and mutation accumulation in aging in light of four Koch-like criteria. They are based on the assumption that some quantitative relationship betwee...

Assessments of disease activity and organ damage in systemic lupus erythematosus (SLE) remain challenging because of the lack of reliable biomarkers and disease heterogeneity. Ongoing inflammation can be difficult to distinguish from permanent organ damage caused by previous flare-ups or medication side effects. Circulating soluble urokinase plasminogen activator receptor (suPAR) has emerged as...

INTRODUCTION Health-related quality of life (HRQOL) is affected by numerous clinical variables, including disease activity, damage, fibromyalgia, depression and anxiety. However, these associations have not yet been described in Mexican patients with systemic lupus erythematosus (SLE). OBJECTIVE To evaluate the relationship between disease activity, damage, depression and fibromyalgia and HRQ...

We analyze the damage initiation, damage progression, and failure during 3-dimensional (3-D) elastoplastic deformations of a fiber reinforced polymeric laminated composite impacted by a low speed rigid sphere, and compare computed results with experimental findings available in the literature. Damage is assumed to initiate when one of Hashin’s failure criteria is satisfied, and its evolution is...

In this research, the maximum stress, Hashin, Puck, LaRC03, and Northwestern University (NU) criteria are analyzed based literature data, analytical results obtained using a MATLAB program numerical from an Abaqus finite-element model. The applicability reliability of these failure for predicting damage in thermoplastic laminates evaluated on results. According to results, stress criterion prov...

The EPA-MARKAL model of the U.S. electricity sector is used to examine how imposing emissions fees based on estimated health and environmental damages might change electricity generation. Fees are imposed on life-cycle emissions of SO(2), nitrogen oxides (NO(x)), particulate matter, and greenhouse gases (GHG) from 2015 through 2055. Changes in electricity production, fuel type, emissions contro...