PURPOSE Dasatinib is a prototypic short half-life BCR-ABL1 tyrosine kinase inhibitor. The recommended dose of dasatinib for chronic myeloid leukemia in chronic phase was changed from 70 mg twice daily to 100 mg once daily following a Phase III dose-optimization study. To better understand the superior benefit-risk profile of dasatinib 100 mg once daily, exposure-response was characterized for e...

BACKGROUND Studies have found that metals are emitted to the electronic cigarette (EC) aerosol. However, the potential health impact of exposure to such metals has not been adequately defined. The purpose of this study was to perform a risk assessment analysis, evaluating the exposure of electronic cigarette (EC) users to metal emissions based on findings from the published literature. METHOD...

The significant role of trace elements in human health is well documented. Trace elements are those compounds that need to be present in the human diet to maintain normal physiological functions. However, some microelements may become harmful at high levels of exposure, or, on the other hand, may give rise to malnutrition, when their exposure is too low. The aim of the present study was to prov...

An experimental assessment of personal exposure to PM10 in 59 office workers was carried out in Dublin; Ireland. Two hundred and fifty five samples of 24 hour personal exposure were collected in real time over a 28 month period. The investigation included an assessment of the uptake of pollutants in the lungs during various daily activities using a Human Respiratory Tract Model. The results of ...

Simultaneous personal measurements of the occupational ultraviolet exposure weighted to the International Commission on Non-Ionising Radiation Protection hazard sensitivity spectrum (UVICNIRP) were made over a five week period (44 person-days) in the second half of the summer school term of 2012 in Queensland, Australia for individual high school teachers located at latitudes of 27.5°S and 23.5...

The aim of this article was to assess the associations of serum 25-hydroxyvitamin D [25(OH)D] and daily sun exposure time with myopia in Korean adults.This study is based on the Korea National Health and Nutrition Examination Survey (KNHANES) of Korean adults in 2010-2012; multiple logistic regression analyses were performed to examine the associations of serum 25(OH)D levels and daily sun expo...

The aim of the present study was to investigate the occurrence of new respiratory symptoms in relation to wood dust exposure in a 6-yr follow-up study. A total of 1,377 woodworkers (1,137 males; 240 females) and 297 reference workers (137 males; 160 females) participated. Data on respiratory symptoms, employment and smoking habits were collected. Wood dust exposure was assessed from baseline du...