An automated fluorescence microscopy assay using a nontoxic cholesterol binding protein, toxin domain 4, (D4), was developed in order to identify chemical compounds modifying intracellular cholesterol metabolism and distribution. Using this method, we screened a library of 1,056 compounds and identified 35 compounds that decreased D4 binding to the cell surface. Among them, 8 compounds were al...

The recent discovery of the new smectic-C(d6)(*) (SmC(d6)(*)) phase [S. Wang et al., Phys. Rev. Lett. 104, 027801 (2010)] also revealed the existence of a noisy region in the temperature window between the SmC(d6)(*) phase and the smectic-C(d4)(*) (SmC(d4)(*)) phase. Characterized by multiple resonant peaks spanning a wide region in Q(Z), the corresponding structure of this temperature window h...

Suramin, a drug that binds to several types of growth factors, has been previously shown to induce the enterocyte-like differentiation of HT29-D4 human colonic adenocarcinoma cells, suggesting that growth factors are involved in such a process. Undifferentiated HT29-D4 cells release insulin-like growth factor II (IGF-II) into the culture medium that is totally complexed to heterogeneous IGF bin...

Vertices of the 4-dimensional semi-regular polytope, snub 24-cell and its symmetry group W (D4) : C3 of order 576 are represented in terms of quaternions with unit norm. It follows from the icosian representation of E8 root system. A simple method is employed to construct the E8 root system in terms of icosians which decomposes into two copies of the quaternionic root system of the Coxeter grou...

The robust “accent culture” of English-language speech in the Irish Republic provides an opportunity to explore the concept of verbal taboo in terms of non-referential indexical function (in this case, phonological variants). The paper documents an ongoing moral panic of language in Irish society, centering on a new and fashionable accent of Irish English. This new accent, termed “D4” (after th...

Let C be a nonsingular plane quintic curve over the complex number field C, and let πP : C → P be a projection from P ∈ C. Let LP be the Galois closure of the field extension C(C)/C(P) induced by πP , where C(C) and C(P) are the rational function fields of C and P, respectively. We call the point P a D4-point if the Galois group of LP /C(P) is isomorphic to the dihedral group D4 of order eight....

Objective To develop a web-enabled Digital Disease Detection Dashboard (D4) that allows users to statistically model and forecast multiple data streams for public health biosurveillance. D4 is a user-friendly, cloudenabled, and R Shiny-powered application that provides intuitive visualization enabling immediate situational awareness through interactive data displays and multi-factor analysis of...

This laboratory study to compare the cleaning efficacy of battery-operated power toothbrushes was carried out in two phases. Firstly, the Braun Oral-B D4/EB4 was compared with the Colgate Actibrush and secondly the D4/EB4 was compared with the Dr. Best Powerclean. All three brushes are battery-operated and have a small round brushhead with an oscillating/rotating action. They differ, however, w...

A continuous random vector (X,Y) uniquely determines a copula C : [0,1]2 → [0,1] such that when the distribution functions of X and Y are properly composed into C , the joint distribution function of (X,Y) results. A copula is said to be D4-invariant if its mass distribution is invariant with respect to the symmetries of the unit square. A D4-invariant copula leads naturally to a family of meas...

In this paper we construct the 2+1 effective theory of the light states in D2/D4-brane system in the context of noncommutative Yang-Mills theory. This effective theory is noncommutative and tachyonic, however, it is not taking the form of an Abelian Higgs model as naively expected. We solve the classical solutions of the effective theory which are nicely corresponding to different states during...