LEA proteins represent severa1 families of proteins that accumulate to high levels in maturing seeds. The expression of these proteins is under developmental control, but they may also be expressed in dissected embryos exposed to exogenous ABA (Hughes and Galau, 1991). Many Leu genes are also expressed in vegetative tissues exposed to exogenous ABA as well as water, osmotic, and low-temperature...

BACKGROUND Preoperative radiochemotherapy (RCT) with 5-FU or capecitabine is the standard of care for patients with locally advanced rectal cancer (LARC). Preoperative RCT achieves pathological complete response rates (pCR) of 10-15%. We conducted a single arm phase II study to investigate the feasibility and efficacy of addition of bevacizumab and oxaliplatin to preoperative standard RCT with ...

INTRODUCTION Optimal preoperative treatment of stage IIB (Pancoast)/III non-small cell lung cancer (NSCLC) remains undetermined and a subject of controversy. The goal of our study is to confirm feasibility and pathological response rates after induction chemoradiation (CRT) in our community-based treatment center. PATIENTS AND METHODS Patients were selected according to functional and resecta...

Background: Conventional methods for susceptibility testing require several months before results can be reported. However, rapid methods to determine drug susceptibility have been developed recently. Phage assay have been reported as a rapid useful tools for antimicrobial susceptibility testing. The aim of this study was to apply the Phage assay for rapid detection of resistance on Mycobacteri...

Background Intratumoral (IT) cancer therapies may enhance T cell activation and tumor infiltration when combined with systemic checkpoint blockade. This approach improve treatment of advanced breast cancer, which is commonly resistant to immune therapy. Methods A multicenter basket-style trial ( NCT02643303 ) was performed in patients solid tumors, who received polyICLC IT 1mg x 6, then intramu...

Liu et al. Journal of Microbiologucal Methods, 51, 369-377, 2002.* Ley et al. Can J Microbiol. 39, 821-825, 1993.* Kono, Advanced Drug Delivery Reviews, 53 307-319, 2001.* “Alteration of Tail Fiber Protein gp38 Enables T2 Phage to Infect Escherichia coli 0157:H7” By: Masatoshi Yoichi, Michiham Abe, Kazuhiko Miyanaga, Hajime Unno, Yasunori Tanji, 2005. “Genome Plasticity in the Distal Tail Fiber...

Liu et al. Journal of Microbiologucal Methods, 51, 369-377, 2002.* Ley et al. Can J Microbiol. 39, 821-825, 1993.* Kono, Advanced Drug Delivery Reviews, 53 307-319, 2001.* “Alteration of Tail Fiber Protein gp38 Enables T2 Phage to Infect Escherichia coli 0157:H7” By: Masatoshi Yoichi, Michiham Abe, Kazuhiko Miyanaga, Hajime Unno, Yasunori Tanji, 2005. “Genome Plasticity in the Distal Tail Fiber...

Liu et al. Journal of Microbiologucal Methods, 51, 369-377, 2002.* Ley et al. Can J Microbiol. 39, 821-825, 1993.* Kono, Advanced Drug Delivery Reviews, 53 307-319, 2001.* “Alteration of Tail Fiber Protein gp38 Enables T2 Phage to Infect Escherichia coli 0157:H7” By: Masatoshi Yoichi, Michiham Abe, Kazuhiko Miyanaga, Hajime Unno, Yasunori Tanji, 2005. “Genome Plasticity in the Distal Tail Fiber...

This paper offers a detailed lesson plan on the forwardbackward algorithm. The lesson is taught from a live, commented spreadsheet that implements the algorithm and graphs its behavior on a whimsical toy example. By experimenting with different inputs, one can help students develop intuitions about HMMs in particular and Expectation Maximization in general. The spreadsheet and a coordinated fol...