BACKGROUND D2-40 has been shown a selective marker for lymphatic endothelium, but also shown in the benign cervical basal cells. However, the application of D2-40 immunoreactivity in the cervical basal cells for identifying the grade of cervical intraepithelial neoplasia (CIN) has not been evaluated. METHODS In this study, the immunoreactive patterns of D2-40, compared with p16(INK4A), which ...

Carbon-11-YM-09151-2 binds highly selectively to D2 dopamine receptors in the brain. Using this ligand, D2 dopamine receptor density (Bmax) and affinity (Kd) in canine striatum were measured. After administering various doses of the ligand in nine experiments, regional uptake was followed by repeated PET scanning for up to 80 min. D2 dopamine receptor specific binding at equilibrium was defined...

SLAC-PUB-1667 (Rev.) November 1975 Revised May 1976 (1) ELECTROLYTIC CONDUCTIVITY DETECTOR FOR TRACE ANALYSIS OF HZ, HD, D2, AND NEON IN HYDROGEN AND DEUTERIUM” E. L. Garwin and A. Roder Stanford Linear Accelerator Center Stanford University, Stanford, California 94305 A gas chromatograph has been developed to detect traces of H2, HD, D2, and neon in hydrogen or deuterium. It uses a stainless s...

The National Mesothelioma Virtual Bank (NMVB) was established to provide annotated biospecimens to the mesothelioma research community. The resource provides tissue microarrays (TMA) to evaluate the biomarkers along with a variety of other resected mesothelioma specimens. In this manuscript, we describe the immunohistochemical evaluation of the mesothelioma TMA with three key antibodies that ar...

Let R be a prime ring with center Z, I nonzero ideal of and D: × → symmetric bi–(α, α)-derivation d the trace D. In present paper, we have considered following conditions: i) [d(x), x]α,α = 0, ii)[d(x), ⊆ Cα,α, iii)(d(x), x)α,α iv)D1(d2(x), x) v)d1(d2(x)) f(x), for all x, y ∈ I, where D1 D2 are two bi-(α, α)-derivations, d1, d2 traces D1, respectively, B: is bi-additive mapping, f B.

DNA sequences of the D2-D3 expansion segments of the 28S gene of ribosomal DNA from 23 taxa of the subfamily Hoplolaiminae were obtained and aligned to infer phylogenetic relationships. The D2 and D3 expansion regions are G-C rich (59.2%), with up to 20.7% genetic divergence between Scutellonema brachyurum and Hoplolaimus concaudajuvencus. Molecular phylogenetic analysis using maximum likelihoo...

Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D1 and D2/3 receptor binding potential (BP), and interpreted them in terms of dopaminergic tone. Th...

The distribution of D1 and D2 receptors was studied in coronal sections of rat brain, using quantitative autoradiography. D1 receptors were labeled with 1.8 nM 3H-SKF-83566 (a brominated analog of 3H-SCH-23390), while D2 receptors were labeled with 1.0 nM 3H-spiroperidol (3H-SPD). The binding of both ligands to sections from brain and from a homogenate of caudate putamen (CPu mash) reached equi...

Dopamine (DA) receptors play an important role in the modulation of excitability and the responsiveness of neurons to activation of excitatory amino acid receptors in the striatum. In the present study, we utilized mice with genetic deletion of D2 or D4 DA receptors and their wild-type (WT) controls to examine if the absence of either receptor subtype affects striatal excitatory synaptic activi...