We have used antisense phosphorothioate oligonucleotides to define the role played by proliferating cell nuclear antigen (PCNA) in neointimal accumulation of smooth muscle cells in a rat carotid artery injury model. The short-term extraluminal delivery of 250 nmol of antisense oligonucleotides, but not control oligonucleotides, immediately after arterial injury produces a 77% suppression of PCN...

We present an accurate algorithm to compute the internal Voronoi diagram and medial axis of a 3-D polyhedron. It uses exact arithmetic and exact representations for accurate computation of the medial axis. The algorithm works by recursively finding neighboring junctions along the seam curves. To speed up the computation, we have designed specialized algorithms for fast computation with algebrai...

We report an extremely rare case of both recurrent lateral patella dislocation and medial patellofemoral instability, following prior operations to correct patella maltracking. Manual translation of the patella revealed medial and lateral instability with a positive apprehension sign. 3-D computer modelling of kinematics based on MRI data demonstrated that the patella deviated laterally at full...

In this report we give an algorithm to construct an approximate medial axis of a connected domain without any holes, in 2-D, also known as the simply connected domain. The first part of the report concentrates on the algorithm which gives the approximate medial axis of a domain bounded by simple, closed C curve. In the second part of the report we look at a modified version of which looks at do...

815 Plast Surg 1998;51:431-5. 2. Hallock GG. The medial sural(MEDIAL GASTROCNEMIUS) perforator local flap. Ann Plast Surg 2004;53:501-5. 3. Innocenti M, Menichini G, Baldrighi C, et al. Are there risk factors for complications of perforator-based propeller flaps for lower-extremity reconstruction? Clin Orthop Relat Res 2014;472:2276-86. 4. Kosutic D, Pejkovic B, Anderhuber F, et al. Complete ma...

Cocaine was administered daily (15 mg/kg, i.p. x 1 d followed by 30 mg/kg, i.p. x 5 d) to produce behavioral sensitization. Using microdialysis in the ventral tegmental area and medial substantia nigra, the effect of repeated cocaine was examined on the extracellular levels of dopamine. One day after discontinuing repeated cocaine injections, an acute challenge with cocaine (15 mg/kg, i.p.) pro...

A method towards robust and efficient medial axis transform (MAT) of arbitrary domains using distance solutions is presented. The distance field, d, is calculated by solving the hyperbolic-natured Eikonal (or Level Set) equation. The solution is obtained on Cartesian grids. Both the fast-marching method and fast-sweeping method are used to calculate d. Medial axis point clouds are then extracte...

The hypothesis that short-duration exercise may ameliorate the decrease in bone mass observed with confinement was investigated with 18 quarter horses (nine colts and nine fillies) weaned at 4 mo of age and placed into box stalls. After a 5-wk adjustment period, individuals were grouped by age and weight, and then divided randomly into three treatment groups: 1) group housed; 2) confined with n...

= Abstract = Vascular proliferative lesion is one of the most important causes of stenosis and late thrombosis in arterial reconstructions. We studied the effect of cyclosporine and dexamethasone on decreasing the hyperplastic response after experimental arterial injury in rats. Ninety female rats were assigned to one of four groups, each receiving daily subcutaneous injections of either (1) sa...

Previous behavioral studies have shown that individuals with autism are less hindered by interference from global processing during the performance of lower-level perceptual tasks, such as finding embedded figures. The primary goal of this study was to examine the brain manifestation of such atypicality in high-functioning autism using fMRI. Fifteen participants with high-functioning autism and...