نتایج جستجو برای: cytotoxic t lymphocyte ctl

تعداد نتایج: 770899  

Journal: :Journal of Investigative Dermatology 2022

Cytotoxic T lymphocyte (CTL) has been found to be activated by cutaneous dendritic cell (DC) in inducible skin-associated lymphoid tissue (iSALT) a murine contact hypersensitivity (CHS) model. Cutaneous DCs are classified into Langerhans (LC), conventional DC1 (cDC1), DC2 (cDC2) and monocyte-derived DC (MoDC); however, which subsets activate CTL within iSALT during the elicitation phase of CHS ...

Journal: :Journal of virology 1994
P Borrow H Lewicki B H Hahn G M Shaw M B Oldstone

Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was noted in four of the five patients studied. T...

Journal: :Blood 2008
Salomé Leibundgut-Landmann Fabiola Osorio Gordon D Brown Caetano Reis e Sousa

The C-type lectin receptor dectin-1 functions as a pattern recognition receptor for beta-glucans and signals via Syk kinase but independently of the Toll-like receptor (TLR) pathway to regulate expression of innate response genes. Dectin-1 signaling can promote activation of dendritic cells (DCs), rendering them competent to prime Th1 and Th17 responses. Here we show that dectin-1-activated DCs...

Journal: :The Journal of clinical investigation 1995
L A Pinto J Sullivan J A Berzofsky M Clerici H A Kessler A L Landay G M Shearer

Identification of the components of protective immunity are crucial for the development of effective prophylactic and therapeutic vaccine strategies. Analysis of HIV-specific responses in exposed but uninfected individuals might thus provide a unique resource to elucidate the components and correlates of protective immunity to HIV. In the present study we analyzed HIV-specific cytotoxic and hel...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Ranran Zhang Mithun Vinod Shah Jun Yang Susan B Nyland Xin Liu Jong K Yun Réka Albert Thomas P Loughran

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by integrating the signaling pathways involved in normal CTL activation and the known deregulations of s...

Journal: :Journal of immunology 1999
A L Zarling J G Johnson R W Hoffman D R Lee

The ability of two different human professional APCs, specifically macrophages (Mphi) and dendritic cells (DC), to stimulate primary responses in human CD8+ T lymphocytes was examined using both allogeneic and Ag-pulsed autologous APCs. CTL responses in CD8+ T lymphocytes isolated from HIV-uninfected donors were evaluated against six different HIV epitopes that are restricted by four different ...

Journal: :The Journal of Experimental Medicine 1977
A Senik BR Bloom

The aims of this study were to define the T-cell subpopulation(s) detected by the virus plaque assay, and particularly to determine whether the virus plaque assay could be used to enumerate cytotoxic T lymphocytes. In addition, studies were undertaken to ascertain whether cell proliferation was required for development of cytotoxic effector function and virus plaque formation by these subpopula...

Journal: :Investigative ophthalmology & visual science 2007
Jared E Knickelbein Sherrie Divito Robert L Hendricks

PURPOSE To examine the acquisition of lytic activity and interferon gamma (IFN-gamma) production by herpes simplex virus (HSV) type 1-specific CD8(+) cytotoxic T-lymphocyte precursors (HSV-CTLps) after exposure to in vitro HSV-1-infected fibroblasts derived from the immunoprivileged cornea (HSV-cFb) or nonprivileged skin (HSV-sFb) or to in vitro HSV-1-infected splenocytes (HSV-Spls) obtained fr...

Journal: Nanomedicine Journal 2018
Piyachat Evelyn Roopngam Roopngam Evelyn Piyachat,

Objective(s): In the current work, poly D, L lactide-co-glycolide (PLGA) particles were applied for a viral vaccine for the delivery of antigens in cytosolic pathway by increasing the antigen presentation to T-lymphocytes. HPV-E7 protein with PLGA particles has been reported as a potent adjuvant for HPV vaccine by encapsulating protein into the PLGA particles. Polysaccharide from Pleurotus sajo...

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