Many signal molecules are involved in mechanotransduction process, among which intracellular calcium and cytoskeleton are two of the most important ones. This study investigated the changes of intracellular calcium and cytoskeleton under pressure and the effects of intracellular calcium variation on cytoskeleton responses to the pressure in rabbit mandibular condylar chondrocytes (MCCs). In vit...

Mesenchymal cell migration on basal lamina is mediated, in part, by the binding of cell surface beta 1,4-galactosyltransferase (GalTase) to specific N-linked oligosaccharides in the E8 domain of laminin. On migrating cells, surface GalTase is anchored to the cytoskeleton; when GalTase is prevented from associating with the cytoskeleton, lamellipodia formation and subsequent migration are inhibi...