<p>Drug-induced cutaneous vasculitis is a known autoimmune complication of tumor necrosis factor (TNF) inhibitors with many instances resulting in the production newly formed antibodies. We report 21-year-old female past medical history Crohn’s disease controlled infliximab who presented to dermatology purpuric rash and crusted plaques her distal lower extremities. Biopsy lesion revealed ...

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare condition that can cause rapid renal failure. Treatment involves steroids and other immunosuppressive agents. Agents for induction include rituximab, cyclophosphamide, pulse dose avacopan.

Background: in vitro maturation (IVM) of oocytes has increasing potential applications in assisted reproductive technology (ART), during which germinal vesicle (GV) oocytes cultured in vitro to produce mature (MII arrested) ones. Although functional, IVM oocytes have low developmental competence compared to in vivo matured oocytes; possibly because IVM comprises asynchrony between nuclear and c...

objective(s) the fractions of candida albicans have been used as an immunomodulator. the present work assessed the effect of different fractions of c. albicans on nitric oxide (no) production by mice peritoneal macrophages. materials and methods cell wall and cytoplasmic fractions of c. albicans atcc 10321 strain were extracted. mice peritoneal macrophages were purified and cultured. different ...

Inflammatory cytokines have a role in triggering cell signals colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor cytokine (SOCs) JAK-STAT. SOCs2 protein is cytoplasmic that can inhibit activation JAK-STAT so it prevents cascade nucleus. This thought to decreased adenocarcinoma co...

Background & Objective: Basal cell carcinoma (BCC) is a common skin cancer arising from the basal layer of the epidermis and its appendages. They are locally invasive, aggressive, and destructive of skin and the surrounding structures. β-Catenin is a multifunctional protein located to the intracellular side of the cytoplasmic membrane coded by the CTNNB1 gene, which maps to chr...

Medicinal plants exerted their antibacterial effects through many mechanisms included inhibition of cell wall synthesis, membrane disruption cytoplasmic membrane, bacterial proteins nucleic acid energy metabolism, as well virulence factors. The current review highlighted the medicinal with activity spectrum action.