The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly. Usually, patients with such symptoms have undergone trephine biopsy. We present the cases of two patients in whom Gaucher disease was suspected because of the discovery of Gaucher cells in trephine biopsy, and subsequently confirmed via enzymatic and mol...

Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome, characterized clinically by fever, splenomegaly, cytopenia, and high ferritin. Infectious causes have been associated with secondary HLH, with viruses being the most common. We report a case of Mycobacterium avium complex-associated HLH in a sickle cell anemia patient. To the best of our knowledge, this association h...

Autoimmune Lymphoproliferative syndrome (ALPS) is an inherited disorder manifesting with autoimmune cytopenia, lymphadenopathy and splenomegaly. The differential diagnosis includes infections, autoimmune disorders or malignancies. The disease is characterized by accumulation of double negative (CD3+ CD4- CD8-) T cells (DNT) in the peripheral blood. We describe a case and review the literature.

Do cy-togenetic abnormalities precede morphologic abnormalities in a developing malignant condition? Eur J Haematol 2007;78: 152-6. 4. Wong KF, Kwong YL. Isochromosome 8q is a marker of secondary acute myeloid leukemia. Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis. et al. 6q deletion detected by fluorescence in situ hybridization using bacterial artificia...

Paroxysmal nocturnal hemoglobinuria is a hematological disorder characterized by hemolytic anemia, cytopenia, and thrombotic events. Venous thrombotic events are more commonly reported. An arterial thrombosis is a rare event in paroxysmal nocturnal hemoglobinuria. We present a case of a 32-year-old female who had symptoms of stroke and on workup, she was diagnosed as a case of paroxysmal noctur...

Background Myelodysplastic syndromes are clonal myeloid disorders marked by ineffective hematopoiesis, cytopenia and qualitative disorders of blood cells that have a variable predilection to undergo clonal evolution to acute myelogenous leukemia. Chronic infection with hepatitis C virus (HCV) induces a chronic stimulation of B lymphocytes and, in some cases, this stimulation can lead to chronic...

Chronic CD8(+) T-cell expansions can result in parotid gland swelling and other organ infiltration in HIV-infected patients, or in persistent cytopenias. We report 14 patients with a CD8+ T-cell expansion to better characterize the clinical spectrum of this ill-defined entity. Patients (9 women/5 men) were 65 year-old (range, 25-74). Six patients had ≥ 1 symptomatic organ infiltration, and 9 ha...

Using Cox models, we established a new prognostic system based on simple clinical parameters in a training series of 232 patients whose diagnoses were made before 1989. Adverse prognostic factors for survival (P <.01) were age 65 years or older, male gender, albumin level lower than 40 g/L, hemoglobin level lower than 12 g/dL, platelet count less than 150 x 10(9)/L, white blood cell count less ...

Dengue is an important viral illness which has the potential to progress into dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Leucopenia and throm-bocytopenia are the hallmarks of acute dengue which normalise with recovery [1]. Progression from thrombo-cytopenia to severe thrombocytosis is uncommon. We describe a patient presenting with acute dengue, who developed extreme reactiv...