نتایج جستجو برای: cytogenetic abnormalities
تعداد نتایج: 112411 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Cytogenetic abnormalities, especially chromosome 13 deletion, are high-risk factors for multiple myeloma. Attaining the highest detection rates of cytogenetic abnormalities is important to provide accurate prognostic information to the referring oncologist. The purpose of this study was to use CT-guided percutaneous fine-needle aspiration bone biopsy (CT-guided FNA) of MR...
BACKGROUND Despite being deliberately targeted to common chromosome aneuploidies, the rapid quantitative fluorescent polymerase chain reaction (QF-PCR) tests can detect the majority of chromosome abnormalities in prenatal diagnosis. The main advantages of this assay are low cost, speed and automation allowing large-scale application. METHODS We developed a QF-PCR test that was applied on 43 0...
Mature B-cell neoplasms are a common group of hematological malignancies in Western counties with the most prevalent being chronic lymphocytic leukemia (CLL). Clonal cytogenetic abnormalities are observed in only 30% of the CLL cases studied by conventional cytogenetic techniques (karyotyping) and up to 80% of the cases studied using the fluorescence in situ hybridization (FISH) technique with ...
BACKGROUND The impact of cytogenetic abnormalities in multiple myeloma after allogeneic stem cell transplantation has not been clearly defined. This study examines whether allogeneic stem cell transplantation could be of benefit for myeloma patients with high-risk cytogenetic abnormalities. DESIGN AND METHODS This is a retrospective multicenter analysis of the registry of the Société Français...
The article describes the cytogenetic parameters of seed progeny Pinus sylvestris plus trees growing in Petrozavodsk orchard first order. P. normal from natural pine phytocenosis Pryazha region (Karelia) were taken as a control. following indicators considered: relative DNA content, number chromosomes, frequency and types mitosis pathologies at metaphase, anaphase telophase stages (in % total d...
introduction: the incidence of chromosomal abnormalities was investigated in untransfered embryos reuslted from in vitro fertilization (ivf) or intracytoplasmic sperm injection (icsi) procedures. materials and methods: a total of 238 embryos of varying morphology between the pronucleated stage and 8-cells were analysed. the cytogenetic method of dyban was used for chromosome preparation. embryo...
Up to 20% of patients with polycythemia vera have karyotypic abnormalities at the time of the initial diagnosis. However, the cytogenetic abnormalities in polycythemia vera have not been well characterized and their prognostic impact is largely unknown. In this study, we aimed to address these issues using a large cohort of polycythemia vera patients with cytogenetic information available. The ...
The discovery of genomic abnormalities present in monoclonal plasma cells has diagnostic, prognostic, and disease-monitoring implications in plasma cell neoplasms (PCNs). However, technical and disease-related limitations hamper the detection of these abnormalities using cytogenetic analysis or fluorescence in situ hybridization (FISH). In this study, 28 bone marrow specimens with known PCNs we...
background: chromosome abnormality (ca) including sex chromosomes abnormality (scas) is one of the most important causes of disordered sexual development and infertility. scas formed by numerical or structural alteration in x and y chromosomes, are the most frequently ca encountered at both prenatal diagnosis and at birth. objective: this study describes cytogenetic findings of cases suspected ...
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