The outlook for patients with advanced ovarian cancer who experience disease relapse following treatment with platinumbased chemotherapy is poor. As well as searching for more effective cytotoxic chemotherapy regimens recent attention has also focused on identifying those agents which have minimal toxicity but still retain clinical activity. In response to the discovery of oestrogen and progest...

OBJECTIVES To investigate melatonin production in hyperandrogenic women before and during treatment with cyproterone acetate and ethinyl estradiol (Diane 35). MATERIAL AND METHODS We studied 10 women with late onset adrenal hyperplasia due to 21-hydroxylase deficiency (LOCAH) and 10 women with idiopathic hirsutism (IH). Patients were treated with Diane 35 for four months. Fasting blood sample...

Combined oral contraceptives In the UK combined oral contraceptives (COCs), containing both oestrogen and progestogen, are the most popular method of contraception for women under age 30. The most common oestrogen used is ethinyl estradiol (EE), in doses between 20 and 35μg. Progestogens are classified according to their steroid structure and the timing of their introduction on to the market. T...

Normal and disturbed testicular descent is frequently approached exclusively through a consideration of the caudal testicular suspensory apparatus. This is surprising, because embryonal gonads develop with both cranial and caudal suspensory ligaments, and the sexes differ with respect to the persistence and development of both the cranial and the caudal ligaments. The current study examined the...

This article gives an overview of current pharmacological treatment of paraphilias and sex offenders focusing on the situation in Germany. Information about selective serotonin reuptake inhibitors (SSRI) is followed by data about established antihormonal substances (cyproterone acetate/CPA, and medroxyprogesterone acetate/MPA), as well as a more detailed account on luteinizing hormone-releasing...

I would like to thank Drs Terplan and Zuckerman for their comments on the recently published position statement, which myself and the other cosignatory authors take very seriously. If I may summarise Drs Terplan and Zuckerman‘s argument. It starts with the assumption that there is now clear evidence proving that levonorgestel (LNG)and norethisterone acetate (NETA)-containing combined oral contr...

ERDAL DINÇ1*, FATIH KAS 1, DUMITRU BALEANU2,3,4 1Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandogan, Ankara, Turkey 2 Çankaya University, Faculty of Arts and Sciences, Department of Mathematics and Computer Science, 06530 Balgat,Ankara,Turkey 3 Institute of Space Sciences, Magurele-Bucharest, P.O. Box, MG-23, R 76911, Romania 4 Faculty of Engineering,King...

OBJECTIVES While there are many suggested reasons for the marked gender bias in cardiovascular events, much of the available data indicate that circulating estrogens are cardioprotective. The possibility that endogenous androgens may be detrimental to the cardiovascular system has received relatively less attention. We investigated the short-term modulatory effects of various concentrations of ...

Parenchymal liver cells were isolated from human liver pieces of surgical waste as well as from rat livers. DNA synthetic activity was measured after different times in primary culture by [3H]thymidine incorporation and autoradiography. Labeling of control cultures of human hepatocytes at densities between 8,000 and 15,000 cells/cm2 was very low (0.4 to 1.3%). Human recombinant epidermal growth...