نتایج جستجو برای: cyp enzyme
تعداد نتایج: 243651 فیلتر نتایج به سال:
Cytochrome P450 (CYP) enzymes are important enzymes involved in drug metabolism. The CYP enzymes are a family of heme proteins involved in the metabolism of numerous toxic and pharmacologically active compounds and can cause drug-drug-interactions with co-administered drugs as well as unwanted adverse side effects. Several in vitro methods have been developed and are in widespread use to evalua...
Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A growing body of evidence supports a strong link between neovascular disease and ...
Eurycoma longifolia (Simaroubaceae) is a popular folk medicine that has traditionally been used in Southeast Asia as an antimalarial, aphrodisiac, antidiabetic, and antimicrobial and in antipyretic remedies. This study evaluates the effects of Eurycoma longifolia extract on cytochrome P450 (CYP) enzyme-mediated drug metabolism to predict the potential for herb-drug interactions. Methanolic extr...
The induction of enzymes is a defensive mechanism for some xenobiotics, but it may alter the drug's safety and efficacy by altering activity metabolic enzymes. One major families involved in phase I metabolism Cytochrome P450 (CYP) which get induced certain drugs. Concomitant administration drugs due to chronic disease or polypharmacy, inducers among them cause toxicity reduce plasma concentrat...
The inhibitory effect of six newly synthesized ethnyl-derivatives on the activity of cytochrome P450 isoenzymes were investigated in rat liver microsomes. 6 μM concentration of each compound against different concentrations of the substrates (1, 2, 4, 8 and 16 μM) was used: 7-ethoxy resorufin "EROD" in β-Naphthoflavone "β-NF"induced CYP 1A isoenzyme and 7-pentoxy resorufin "PROD" in phenobarbit...
OBJECTIVE Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency (ORD) present with disordered sex development and glucocorticoid deficiency. This is due to disruption of electron transfer from mutant POR to microsomal cytochrome P450 (CYP) enzymes that play a key role in glucocorticoid and sex steroid synthesis. POR also transfers electrons to all major drug-m...
The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine. However, it has been reported that epinephrine and adrenochrome can be metabolized by hepatic microsomes ...
In order to map cyclosporin A (CsA) binding sites of cyclophilin (CyP), we synthesized the complete set of overlapping 157 octapeptides corresponding to human CyP A using the multi-pin peptide synthesis system. The pin-coupled synthetic octapeptides were examined in terms of binding ability to CsA by a modification of the enzyme-linked immunosorbent assay. Significant binding of CsA was detecte...
The extract of Hedera helix L. (Araliaceae), a well-known folk medicine, has been popularly used to treat respiratory problems, worldwide. It is very likely that this herbal extract is taken in combination with conventional drugs. The present study aimed to evaluate the effects of H. helix extract on cytochrome P450 (CYP) enzyme-mediated metabolism to predict the potential for herb-drug interac...
Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than their corresponding activities in primary hepatocytes, and thus these cell lines may not accurately predict drug metabolism. In the present study, we selecte...
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