The present study shows the advantages of liposome-based nano-drugs as a novel strategy of delivering active pharmaceutical ingredients for treatment of neurodegenerative diseases that involve neuroinflammation. We used the most common animal model for multiple sclerosis (MS), mice experimental autoimmune encephalomyelitis (EAE). The main challenges to overcome are the drugs' unfavorable pharma...

Background: Eptifibatide (Integrilin®) is a hepta-peptide drug which specifically prevents the aggregation of activated platelets. The peptide drugs are encapsulated into nanolipisomes in order to decreasing their side effects and improving their half-life and bioavailability. Objectives: In this study, the in vitro cytotoxicity and hemocompatibi...

Desmopressin acetate is a potent synthetic peptide hormone. A more acceptable route of Desmopressin acetate is a potent synthetic peptide hormone. That is administered via parenteral, intranasal, and oral routes. A more acceptable route of administration with potentially good bioavailability could be offered by transdermal delivery. The present work reports on the development of water-in-oil (w...

The design hypothesis, architectures, and preliminary computational results of a peptide based nanoTweezer are presented in this paper. We engineered the α-helical coiled coil portion of the yeast transcriptional activator peptide called GCN4 to obtain an environmentally-responsive nanoTweezer. The dimeric coiled coil peptide consists of two identical ~4.5 nm long and ~3 nm wide polypeptide cha...

Abstract. Carbon fiber reinforced (CFR) composite rings with and without interlaminar carbon nanotubes (I-CNTs) were manufactured starting from high performance prepregs used in aeronautics. Nano-particles deposition was obtained by an innovative easily scalable procedure which does not affect processability. A CNTs-solvent solution sonicated for established time to reduce bulk CNTs agglomerate...

Modern nano-HPLC systems are capable of extremely precise control of solvent gradients, allowing high-resolution separation of peptides. Most proteomics laboratories use a simple linear analytical gradient for nano-LC-MS/MS experiments, though recent evidence indicates that optimized non-linear gradients result in increased peptide and protein identifications from cell lysates. In concurrent wo...

There is an important number of thermoelectric applications in the range medium temperatures (between 200 and 600 °C), such as heat recovery automotive applications, where these are easily reached exhaust or motor. Among various materials which exhibit good properties this range, Skutterudites (with general formula CoSb3) stand out some most used. In recent years, different improvements have be...