Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes DDC-Cu with hydroxypropyl beta-cyclodextrin (HP) or sulfobutyl ether (SBE) were prepared and investigated as an approach to enhance the apparent solubility DDC-Cu. F...

Zerumbone (ZER) isolated from Zingiber zerumbet was previously encapsulated with hydroxypropyl- β -cyclodextrin (HP β CD) to enhance ZER's solubility in water, thus making it highly tolerable in the human body. The anticancer effects of this new ZER-HP β CD inclusion complex via apoptosis cell death were assessed in this study for the first time in liver hepatocellular cells, HepG2. Apoptosis w...

Propanidid is a short acting anaesthetic with poor solubility in water. It was formerly marketed for clinical use as an intravenous (i.v.) anaesthetic in Cremophor EL (Epontol, propanidid 50 mg ml) but this was withdrawn due to anaphylactoid reactions to the vehicle. This paper reports on an aqueous formulation using hydroxypropyl-b-cyclodextrin (HP-b-CD) as a solubiliser. Phase solubility anal...

Background: Hydrolysis of 2-amino phenylpropionitrile by nitrilase is a fundamental biochemical reaction that produces chiral phenylalanine. For practical application of this biochemical reaction, researchers have attempted to improve enzyme enantioselectivity and the reaction rate. Results: The substrate concentration was increased from 100 to 200 mM without substrate inhibition because of the...

Mesoporous silica nanoparticles (MSNs) have sparked considerable interest in drug/gene delivery, catalysis, adsorption, separation, sensing, antireflection coatings and bioimaging because of their tunable structural properties. The shape, size and pore structure of MSNs are greatly influenced by the type of additives used, e.g., solvent and pore-templating agent. Here, we studied the influence ...

The formation of an inclusion compound between a naphthoquinone derivative (I) and HP-ß-CD was studied in solid state by X-ray diffractometry, DSC, and IR. Introduction The formation of inclusion complexes with cyclodextrins constitutes a widely used strategy to increase the aqueous solubility and to decrease the countereffects of many drugs. Isoxazolylnaphthoquinones belong to a family of comp...

BACKGROUND Targeted delivery of small interfering RNA (siRNA) has been regarded as one of the most important technologies for the development of siRNA therapeutics. However, the need for safe and efficient delivery systems is a barrier to further development of RNA interference therapeutics. In this work, a nontoxic and efficient siRNA carrier delivery system of low molecular weight polyethylen...

The formation of associative networks in semidilute aqueous solutions of hydrophobically modified hydroxyethylcellulose (HM-HEC) is dependent on intermolecular hydrophobic interactions. Addition of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) monomers to the system provides decoupling of these associations via inclusion complex formation with the polymer hydrophobic tails. Results from viscosit...

Systemic administration of chemotherapy for cancer often faces drug resistance, limiting its applications in cancer therapy. In this study, we developed a simple multifunctional nanocarrier based on polyethylenimine (PEI) to codeliver doxorubicin (DOX) and BCL2 small interfering RNA (siRNA) for overcoming multidrug resistance (MDR) and enhancing apoptosis in MCF-7/Adr cancer cells by combining ...

Cutaneous wound healing is accelerated by mechanical stretching, and treatment with hyperforin, a major component of a traditional herbal medicine and a known TRPC6 activator, further enhances the acceleration. We recently revealed that this was due to the enhancement of ATP-Ca2+ signaling in keratinocytes by hyperforin treatment. However, the low aqueous solubility and easy photodegradation im...