• This review examines critically the evidence bearing on the hypothesis that the positive inotropic effects of catecholamines are mediated by intracellular cyclic adenosine monophosphate (cyclic AMP). The review is selective in several respects. For example, it does not contain extensive discussions about the biochemical actions of cyclic AMP, the enzymes regulating its synthesis and degradati...

experimental study of the cyclic behavior of unsaturated materials is more complex than that of the saturated materials due to the required equipment, experience and time. furthering investigations in the field of unsaturated materials is necessary to better understand its complexity and sensitivity of unsaturated cyclic parameters to different determinants such as suction path, stress path, lo...

OBJECTIVE The purpose of this study was to determine the effect of cyclic strain on Notch signaling in endothelial cells. METHODS AND RESULTS Exposure of human endothelial cells (ECs) to cyclic strain (10%) resulted in temporal upregulation of Notch receptors (1 and 4) at the mRNA and protein level. Cyclic strain significantly increased EC network formation on Matrigel (an index of angiogenes...

The cyclic derivative was introduced by G.-C. Rota, B. Sagan and P. R. Stein in [3] as an extension of the derivative to noncommutative polynomials. Here we show that there are simple necessary and sufficient conditions for an n-tuple of polynomials in n noncommuting indeterminates to be a cyclic gradient (see Theorem 1) and similarly for a polynomial to have vanishing cyclic gradient (see Theo...

anti-müllerian hormone (amh) has been observed to decrease with the development of hemorrhagic anovulatory follicles (hafs) in mares. two studies were conducted to evaluate amh concentration in mares with hafs compared to seasonally anoestrous and cyclic mares, and to elucidate changes of amh with the development of luteinised unruptured follicles (lufs). in study 1, amh and progesterone were e...

The roles of cyclic AMP and cyclic AMP-dependent protein kinase in the contractile and metabolic responses to neural stimulation were studied in the bullfrog heart perfused in situ. The interaction of parasympathetic and sympathetic nerves in the regulation of myocardial cyclic AMP, cyclic AMP-dependent protein kinase, and phosphorylase also was studied. Stimulation of the left vagosympathetic ...

Numerical modeling was carried out to investigate the responses of suction bucket foundations under vertical cyclic loading. Numerical results were compared with centrifuge experiment results. Before the capacity of the model suction bucket to resist cyclic loading could be investigated, the static pullout capacities had to be determined. The buckets with different aspect ratio are investigated...

‎‎A natural generalization of two dimensional cyclic code ($T{TDC}$) is two dimensional skew cyclic code‎. ‎It is well-known that there is a correspondence between two dimensional skew cyclic codes and left ideals of the quotient ring $R_n:=F[x,y;rho,theta]/_l$‎. ‎In this paper we characterize the left ideals of the ring $R_n$ with two methods and find the generator matrix for two dimensional s...

1 In this study we examined the endothelium-dependent effect of YC-1 - a benzyl indazole derivative which directly activates soluble guanylyl cyclase (sGC) - on vascular relaxation and nitric oxide (NO) and guanosine-3',5'-cyclic monophosphate (cyclic GMP) in endothelial cells. 2 In preconstricted rat aortic rings with intact endothelium, YC-1 produced a concentration-dependent relaxation. Howe...

The effects of acetylcholine, ischemia, and anoxia on myocardial cyclic GMP and cyclic AMP were investigated in isolated rat hearts perfused under either constant flow (14 ml/min) or constant pressure (100 cm H,O) conditions with physiological saline gassed with 95% O,-5% COj. In paced, constant flow-perfused hearts, cyclic GMP increased from a control of 35 to 62 fmol/mg protein and remained e...