نتایج جستجو برای: cyanex 302

تعداد نتایج: 6187  

2010
George Bebis

(d) Suppose list1 contains N1 elements and list2 contains N2 elements. The first while loop is executed O(N1) times. The body of this loop takes O(N1) since GetNextItem takes O(1) and InsertItem takes O(N1). So, the complexity of the first loop is O(N1N1). The second while loop is executed O(N2) times. The body of that loop takes O(N1+N2) time since GetNextItem takes O(1), RetrieveItem takes O(...

Journal: :cell journal 0

objective: mir-302-367 is a cluster of polycistronic micrornas that are exclusively expressed in embryonic stem (es) cells. the mir-302-367 promoter is functional during embryonic development but is turned off in later stages. motivated by the cancer stem cell hypothesis, we explored the potential expression of mir-302 in brain tumor cell lines. materials and methods: in the present experimenta...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
M Sahin-Toth H R Kaback

A mechanistic model for lactose/H(+) symport via the lactose permease of Escherichia coli proposed recently indicates that the permease must be protonated to bind ligand with high affinity. Moreover, in the ground state, the symported H(+) is shared between His-322 (helix X) and Glu-269 (helix VIII), whereas Glu-325 (helix X) is charge-paired with Arg-302 (helix IX). Substrate binding at the ou...

2016
Lin Zhao Yan Wang Longyang Jiang Miao He Xuefeng Bai Lifeng Yu Minjie Wei

BACKGROUND The importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor chemoresistance has not been fully understood. Previously, we found two novel MDR-associated microRNAs (miRNAs). In this report, we investigated the combined effects of miRNA gene cluster in chemoresistance of breast cancer. METHODS This study wa...

2015
Sarah G.J.A. Peeters Catharina M.L. Zegers Rianne Biemans Natasja G. Lieuwes Ala Yaromina Jessica D. Sun Charles P. Hart Ludwig J. Dubois Philippe Lambin

Purpose:Conventional anticancer treatments are often impaired by thepresenceofhypoxia. TH-302selectively targetshypoxic tumor regions, where it is converted into a cytotoxic agent. This study assessed the efficacy of the combination treatment of TH-302 and radiotherapy in two preclinical tumor models. The effect of oxygen modification on the combination treatment was evaluated and the effect of...

Journal: :Journal of clinical microbiology 2012
Chivonne Moodley Mignon du Plessis Kedibone Ndlangisa Linda de Gouveia Keith P Klugman Anne von Gottberg

From August 1999 through July 2002, hyperinvasive Neisseria meningitidis serogroup B (MenB) clonal complexes (CCs), namely, ST-32/ET-5 (CC32) and ST-41/44/lineage 3 (CC41/44), were predominant in the Western Cape Province of South Africa. This study analyzed MenB invasive isolates from a national laboratory-based surveillance system that were collected from January 2002 through December 2006....

پایان نامه :وزارت علوم، تحقیقات و فناوری - پژوهشگاه ملی مهندسی ژنتیک وزیست فناوری 1392

کلاستر mir-302 به عنوان microrna غالب در سلول های بنیادی جنینی شناخته شده است که در هنگام تمایز، بیان این کلاستر کاهش می یابد. محققین نشان داده اند که ترنسفکشن برخی از رده های سلولی سرطانی با وکتور حاوی کلاستر mir-302 به برنامه نویسی مجدد در ? درصد سلول ها و تشکیل سلول های شبه بنیادی جنینی منجر می شود که این سلول ها نسبت به سلول های سرطانی سرعت تقسیم سلولی کمتری دارند.

Journal: :Chemie Ingenieur Technik 2021

Indium separation using ion exchange resins from acidic polymetallic and very diluted solutions are investigated. Since the selectivity of commercial have proven to be too low for an effective with high content other metals, Lewatit® TP 208 was impregnated common extractants enhance its properties. By resin impregnation D2EHPA Cyanex 272, not only selective indium recovery reached but also capa...

Journal: :Archives of Cardiovascular Diseases Supplements 2013

2014
Yoichi Takakusagi Shingo Matsumoto Keita Saito Masayuki Matsuo Shun Kishimoto Jonathan W. Wojtkowiak William DeGraff Aparna H. Kesarwala Rajani Choudhuri Nallathamby Devasahayam Sankaran Subramanian Jeeva P. Munasinghe Robert J. Gillies James B. Mitchell Charles P. Hart Murali C. Krishna Ester Hammond

BACKGROUND TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia in tumors. We investigated the mechanism underlying the induction of transient hypoxia and the combination use of pyruvate to potentiate...

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