نتایج جستجو برای: cxcl1

تعداد نتایج: 1727  

Journal: :The Journal of clinical investigation 2012
Antonio Citro Elisa Cantarelli Paola Maffi Rita Nano Raffaella Melzi Alessia Mercalli Erica Dugnani Valeria Sordi Paola Magistretti Luisa Daffonchio Pier Adelchi Ruffini Marcello Allegretti Antonio Secchi Ezio Bonifacio Lorenzo Piemonti

Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered by immune system rejection of engrafted tissue. The identification of pathways that regulate post-transplant detrimental inflammatory events would improve management and outcome of transplanted patients. Here, we found that CXCR1/2 chemokine receptors and their ligan...

2014
Martin David H. Eidelman Qutayba Hamid Laila A. Al-Alwan Ying Chang Simon Rousseau James G. Martin

Airway smooth muscle cell (ASMC) migration is an important mechanism postulated to play a role in airway remodeling in asthma. CXCL1 chemokine has been linked to tissue growth and metastasis. In this study, we present a detailed examination of the inhibitory effect of CXCL1 on human primary ASMC migration and the role of the decoy receptor, Duffy AgR for chemokines (DARC), in this inhibition. W...

2009
R. C. Reis A. C. Fabian R. R. Ross J. M. Miller

We present measurements of the dimensionless spin parameters and inner-disc inclination of two stellar-mass black holes. The spin parameter of SWIFT J1753.5−0127 and GRO J1655−40 is estimated by modelling the strong reflection signatures present in their XMM– Newton observations. Using a newly developed, self-consistent reflection model which includes the blackbody radiation of the disc as well...

Journal: :Iranian journal of immunology : IJI 2013
Nahid Zainodini Gholamhossein Hassanshahi Mohammad Kazemi Arababadi Hossein Khorramdelazad Afshin Mirzaei

BACKGROUND Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 serve as T lymphocytes recruiters. OBJECTIVE To study the serum levels of EL...

Journal: :Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2013
Michael R Pranzatelli Elizabeth D Tate Nathan R McGee Jerry A Colliver

To define cytokine concentrations and detectability in children with noninflammatory neurological disorders (NIND). The multiplex bead assay technology was used for simultaneous measurement of 34 soluble cytokines/chemokines in cerebrospinal fluid (CSF) from 73 NIND. Sera from 36 healthy children and 37 NIND also were analyzed. In CSF, CXCL10 had the highest concentration; CCL2, CXCL10, and int...

Journal: :Carcinogenesis 2012
Peter H Killian Emanuel Kronski Katharina M Michalik Ottavia Barbieri Simonetta Astigiano Christian P Sommerhoff Ulrich Pfeffer Andreas G Nerlich Beatrice E Bachmeier

In America and Western Europe, prostate cancer is the second leading cause of death in men. Emerging evidence suggests that chronic inflammation is a major risk factor for the development and metastatic progression of prostate cancer. We previously reported that the chemopreventive polyphenol curcumin inhibits the expression of the proinflammatory cytokines CXCL1 and -2 leading to diminished fo...

Journal: :Journal of the American Society of Nephrology : JASN 2011
Ali Akcay Quocan Nguyen Zhibin He Kultigin Turkmen Dong Won Lee Ana Andres Hernando Christopher Altmann Aysun Toker Arijana Pacic Danica Galesic Ljubanovic Alkesh Jani Sarah Faubel Charles L Edelstein

Inflammation contributes to the pathogenesis of acute kidney injury (AKI). IL-33 is a proinflammatory cytokine, but its role in AKI is unknown. Here we observed increased protein expression of full-length IL-33 in the kidney following induction of AKI with cisplatin. To determine whether IL-33 promotes injury, we administered soluble ST2 (sST2), a fusion protein that neutralizes IL-33 activity ...

1999
David L. Meier

A model for GROJ1655-40 is described in which the hard X/~-ray behavior, and long delay between the X/~ and radio outbursts, are explained by processes which occur when the accretion rate approaches and exceeds the Eddington limit. The principal feature of the model is a dense, optically thick, super-Eddington wind ejected from the center of the accretion disk. The wind is responsible for deter...

Journal: :Frontiers in Cardiovascular Medicine 2021

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