Abstract Aims Laparoscopic cholecystectomy (LC) is known to be one of the most widely performed general surgical operations. However, it still associated with an increased incidence and severity complications especially during period a surgeon’s proficiency-gain curve. Certain could prevented by decreasing consequences surgeon errors. We aimed systematically review use checklists LC their effec...

Lung cancer (LC) is one of the most serious cancers threatening human health. Histopathological examination gold standard for qualitative and clinical staging lung tumors. However, process doctors to examine thousands histopathological images very cumbersome, especially with less experience. Therefore, objective pathological diagnosis results can effectively help choose appropriate treatment mo...

Binary logistic regression has been used to estimate the probability of lane change (LC) in Cell Transmission Model (CTM). These models remain rigid, as flexibility predict LC for different cell size configurations not accounted for. This paper introduces a relaxation method refine conventional binary model using an event-tree approach. The increasing and length was estimated by expanding pre-d...

BMCL26 is a potential drug derived from nimesulide, which has exhibited the substantial anti-parasitic activity in various cell lines. To conduct various pharmacological and toxicological properties of this drug, we developed and validated a rapid LC-MS/MS method for its quantification in accordance with the FDA guidelines. Protein precipitation with 0.1% formic acid in acetonitrile was used to...

The pharmacokinetic behavior of allixin (3-hydroxy-5-methoxy-6-methyl-2-penthyl-4H-pyran-4-one) was investigated in an experimental animal, mice. Allixin was administered using an inclusion compound because the solubility of allixin in aqueous solution is very low. The allixin content in serum and in the organs of administered animals was analyzed by liquid chromatography (LC)-MS. Most of the a...

A high throughput sample preparation method was developed utilizing mixed-mode solid phase extraction (SPE) in 96-well plate format for the determination of free arachidonic acid in plasma by LC-MS/MS. Plasma was mixed with 3% aqueous ammonia and loaded into each well of 96-well plate. After washing with water and methanol sequentially, 3% of formic acid in acetonitrile was used to elute arachi...

A highly sensitive liquid chromatographic mass spectrometric (LC-MS/MS) method for determination of pantoprazole in rat plasma using omeprazole as the internal standard (IS) was developed. Plasma samples were precipitated by acetonitrile and separated on a Zorbax SB-C18 column with gradient profile at a flow of 0.4 mL/min. Detection was carried out by SIM mode on an ion-trap LC-MS/MS system wit...