OBJECTIVE Peripheral blood CD34(+) cells from diabetic patients demonstrate reduced vascular reparative function due to decreased proliferation and diminished migratory prowess, largely resulting from decreased nitric oxide (NO) bioavailability. The level of TGF-beta, a key factor that modulates stem cell quiescence, is increased in the serum of type 2 diabetic patients. We asked whether transi...

OBJECTIVE To examine the effects of three different school snacks on morbidity outcomes. DESIGN Twelve schools were randomized to either one of three feeding groups or a Control group. There were three schools per group in this cluster randomized trial. Children in feeding group schools received school snacks of a local plant-based dish, githeri, with meat, milk or extra oil added. The oil us...

The development of antisense oligonucleotide therapy is an important advance in the identification of corrective therapy for neuromuscular diseases, such as spinal muscular atrophy (SMA). Because of difficulties of delivering single-stranded oligonucleotides to the CNS, current approaches have been restricted to using invasive intrathecal single-stranded oligonucleotide delivery. Here, we repor...

Chiral periodic mesoporous organosilica (PMO) materials have been shown to deracemize a configurationally achiral, but conformationally racemic liquid crystal in which the PMO is embedded. In particular, application of an electric field E in the liquid crystal’s smectic-A phase results in a rotation of the liquid crystal director by an angle proportional to E, which is detected optically — this...

Over the past decade, increasing use of the immunomodulatory derivatives (IMiDs) thalidomide and lenalidomide and the first-inclass proteasome inhibitor bortezomib has dramatically changed the natural history of multiple myeloma (MM).2 Novel agents, initially approved for the treatment of relapsed or refractory (rel/refr) MM, are actually used up-front as part of induction therapy for both tran...

A series of complex organic-inorganic mesoporous materials were successfully synthesized by a microwave-assisted method that allowed the preparation periodic organosilicas (PMOs) with Ti (IV) forming part structure (Ti-PMOs). Materials characterized using N2 adsorption–desorption isotherms, powder X-ray diffraction (XRD), transmission and high resolution electron microscopy (TEM HRTEM), Raman, ...

Responsive PMO materials have been synthesized through co-assembly of bridged diacetylenic silsesquioxane and surfactant. The spatially defined polydiacetylenic component, mesoporous network, and the covalent proximity of polydiacetylene to silica endow the PMO with mechanical robustness, reversible chromatic responses, improved thermal stability, and faster responses to chemical stimuli. This ...

A periodic mesoporous organosilica (PMO) with nanorice morphology was successfully synthesized by a template assisted sol-gel method using a chain-type precursor. The PMO is composed of D and T sites in the ratio 1:2. The obtained mesoporous nanorice has a surface area of 753 m(2) g(-1), one-dimensional channels, and a narrow pore size distribution centered at 4.3 nm. The nanorice particles hav...

Many organizations today have recognized the need for a project management office (PMO) to achieve project management oversight, control, and support. The PMO’s role is to help both the project manager and the relevant organization to not only understand and apply modern project management practices, but also to adapt and integrate business interests into the organization’s project management e...