objective(s) as there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (vpa), this study was conducted to investigate the relationship between patient demographic characteristics, vpa dosage and the drug clearance in adult iranian patients. materials and methods patients (n= 47) were either on monotherapy with vpa or were under co...

PURPOSE The (6-maleimidocaproyl)hydrazone derivative of doxorubicin (DOXO-EMCH) is an albumin-binding prodrug of doxorubicin with acid-sensitive properties that shows superior antitumor efficacy in murine tumor models and a favorable toxicity profile in mice, rats, and dogs compared with doxorubicin. The purpose of the phase I study was to characterize the toxicity profile of DOXO-EMCH, establi...

OBJECTIVE Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy was developed to provide a cortisol exposure-time profile that closely resembles the physiological cortisol profile. This study aimed to characterize single-dose pharmacokinetics (PK) of DR-HC 5-20mg and assess intrasubject variability. METHODS Thirty-one healthy Japanese or non-Hispanic Caucasian volunteers age...

Introduction: To investigate the possible role of sentinel lymph node biopsy (SLNB) to upstage the N0 neck in patients with oral and oropharyngeal squamous cell carcinoma. Methods: Patients with T1-T2 oral and oropharyngeal squamous cell carcinoma accessible to injection and staged N0 into the neck by palaption and CTscan were enrolled in the study. All patients underwent regular follow-up to i...

BACKGROUND Elevated intracranial pressure (ICP) is a common cause of death in acute liver failure (ALF) and is determinant for decision-making regarding the timing of liver transplantation. The recommended type ICP monitoring device is controversial in ALF patients. Epidural devices had less risk of hemorrhagic complications, but they are less reliable than intraparenchymal ones. METHOD Twent...

Background: This work investigated the dosimetry limitations of the random and systematic uncertainties of sliding window (SW) intensity modulated radiation therapy (IMRT). Materials and Methods: A Varian 21EX linear accelerator, Pinnacle3 treatment planning system and radiographic film dosimetry was used. The limitations of the SW were studied using beam modulation ranging from 2 to 10...

A 33-year-old woman with a history of psoriasis presented with asymmetric oligoarthritis. She had no cardiovascular symptoms. Naproxen and steroids were started with the diagnosis of psoriatic arthritis. Routine chest X-ray showed a small left hemithorax with a right-sided aortic arch and decreased left-sided pulmonary vasculature. A CTscan (Picture A) demonstrated the absence of the left pulmo...