The essential zinc finger protein ASCIZ (also known as ATMIN, ZNF822) plays critical roles during lung organogenesis and B cell development in mice, where it regulates the expression of dynein light chain (DYNLL1/LC8), but its functions in other species including invertebrates are largely unknown. Here we report the identification of the Drosophila ortholog of ASCIZ (dASCIZ) and show that loss ...

OBJECTIVE To systematically evaluate and compare the diagnostic accuracy of CT perfusion (CTP), non-enhanced computed tomography (NCCT) and computed tomography angiography (CTA) in detecting acute ischemic stroke. METHODS We searched seven databases and screened the reference lists of the included studies. The risk of bias in the study quality was assessed using QUADASII. We produced paired f...

CTP synthase is an essential enzyme that plays a key role in energy metabolism. Several independent studies have demonstrated that CTP synthase can form an evolutionarily conserved subcellular structure termed cytoophidium. In budding yeast, there are two isoforms of CTP synthase and both isoforms localize in cytoophidium. However, little is known about the distribution of CTP synthase isoforms...

Our previous work has shown that incubation of K562 cells or lymphocytes from patients with advanced chronic lymphocytic leukemia (CLL) with arabinosyl-2-fluoroadenine (F-ara-A) potentiates the rate of arabinosylcytosine 5'-triphosphate (ara-CTP) synthesis during subsequent treatment with arabinosylcytosine (ara-C). To test the biochemical modulation of ara-CTP in a clinical setting, we designe...

Newly developed coated wire electrodes have been developed for determination of cefditoren pivoxil (CTP) in pure form, pharmaceutical preparations and in biological fluids. The selective electrodes were fabricated based on the incorporation of cefditoren pivoxil with the ion exchangers, phosphomolybdic acid (CTP-PMA), phosphotungstic acid (CTP-PTA) and a mixture of both (CTP-PMA/PTA). The poten...

The current role of CT perfusion (CTP) imaging in the diagnosis and treatment of vasospasm in the setting of aneurysmal subarachnoid hemorrhage is discussed in this article, with specific attention directed towards defining the terminology of vasospasm and delayed cerebral ischemia. A commonly used CTP technique in clinical practice is described. A review of the literature regarding the usefuln...

BACKGROUND AND PURPOSE DCI is a serious complication following aneurysmal SAH and remains a leading cause of morbidity and mortality. Our aim was to evaluate CTP in aneurysmal SAH by using outcome measures of DCI. MATERIALS AND METHODS This was a retrospective study of consecutive patients with SAH enrolled in a prospective institutional review board-approved clinical accuracy trial. Qualitat...

Resumo O apoio matricial (AM) se divide em duas dimensões: assistencial e técnico-pedagógica. interesse desta revisão está no caráter técnico-pedagógico (CTP) do AM, por seu potencial para a transformação das práticas saúde da organização trabalho. Este estudo pretende analisar, meio de bibliográfica exploratória, como o CTP vem sendo abordado na literatura. Parte-se hipótese que assim tal dime...

P ercutaneous coronary intervention with stents is currently the most commonly performed coronary revascularization procedure. 1 Two types of coronary stents, bare metal stent and drug-eluting stent (DES), are used. 1 The main complications of stent implantation are in-stent restenosis and stent thrombosis. DES reduced the incidence of restenosis compared with bare metal stent. However, the occ...

P2X receptors are trimeric ATP-gated cation channels involved in diverse physiological processes, ranging from muscle contraction to nociception. Despite the recent structure determination of the ATP-bound P2X receptors, the molecular mechanism of the nucleotide base specificity has remained elusive. Here, we present the crystal structure of zebrafish P2X4 in complex with a weak affinity agonis...