نتایج جستجو برای: csf3
تعداد نتایج: 99 فیلتر نتایج به سال:
The landscape of recurrent genetic events in AML has been elegantly unraveled in recent years; however, for most disease subsets this has not yet led to facile deployment of therapeutics targeting aberrant genetic events. The resulting gap in our ability to decipher genetic drivers versus our capacity to harness this knowledge for therapeutic advantage will require the integration of genotype i...
BACKGROUND The molecular causes of many hematologic cancers remain unclear. Among these cancers are chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL1-negative) chronic myeloid leukemia (CML), both of which are diagnosed on the basis of neoplastic expansion of granulocytic cells and exclusion of genetic drivers that are known to occur in other myeloproliferative neoplasms and myeloproli...
The activities of four purified human growth factors: biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor (GM-CSF); recombinant erythroid-potentiating activity (EPA); natural and recombinant pluripoietin (Ppo); and natural pluripoietin alpha (Ppo alpha), were compared on the growth of hematopoietic colonies from enriched populations of human marrow and blood progenitor c...
In previous studies that have profiled gene expression in patients with complex regional pain syndrome (CRPS), the expression of granulocyte colony-stimulating factor 3 receptor (G‑CSFR) was elevated, as were a number of pain‑associated genes. The present study determined the expression of G‑CSFR and the mechanisms by which it may affect hypersensitivity, focusing on the signal transducer and a...
Background Case fatality rates among hospitalized patients diagnosed with human immunodeficiency virus (HIV)-associated tuberculosis remain high, and tuberculosis mycobacteremia is common. Our aim was to define the nature of innate immune responses associated with 12-week mortality in this population. Methods This prospective cohort study was conducted at Khayelitsha Hospital, Cape Town, Sout...
Chronic neutrophilic leukemia (CNL) is a BCR::ABL1-negative myeloproliferative neoplasm (MPN) characterized by sustained peripheral blood (PB) neutrophilia (white cell count ≥ 25×109/L, with ≥80% neutrophils), bone marrow (BM) hypercellularity due to granulocyte proliferation without excess of blast or dysplasia. Somatic mutations CSF3R gene, encoding the colony stimulating factor (G-CSF) recep...
Mutations in CSF3R have been recently defined as the common genetic event in patients with myeloid neoplasms, including the rare entity known as chronic neutrophilic leukemia (CNL), becoming a potentially useful biomarker for diagnosing and therapy target. CSF3R encodes the transmembrane receptor for granulocyte colony-stimulating factor (G-CSF; CSF3), which provides the proliferative and survi...
One hundred eighty-nine human tumor specimens were tested in a human tumor cloning assay to determine their growth response to human recombinant granulocyte-macrophage colony-stimulating factor. Of these samples 48 were évaluable for response. Growth stimulation to >150% of controls was noted in 1 of 12 lung cancers (8%) and 1 of 14 breast cancers (7%) but in no other instances for an overall ...
Dear Editor Recently, the mutations within the colony-stimulating factor 3 receptor gene (CSF3R) have been reported as a specific marker of chronic neutrophilic leukemia (CNL) and atypical CML (aCML) [1, 2]. The current WHO system classifies CNL as a BCR-ABL1negative myeloproliferative neoplasm (MPN). However, in routine clinical practice, it is difficult to clearly distinguish CNL from aCML, c...
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