The cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self-renewing cell populations that constitute the bulk of the tumor. Although, the CSC hypothesis does not directly address the cell of origin of cancer, it is postulated that tissue-resident stem or progenitor cells are the most common ...

Resistance to therapy and lack of curative treatments for metastatic breast cancer suggest that current therapies may be missing the subpopulation of chemoresistant and radioresistant cancer stem cells (CSC). The ultimate success of any treatment may well rest on CSC eradication, but specific anti-CSC therapies are still limited. A comparison of the transcriptional profiles of murine Her2(+) br...

BACKGROUND Accumulating evidence has shown that different immunotherapies for ovarian cancer might overcome barriers to resistance to standard chemotherapy. The vaccine immunotherapy may be a useful one addition to conditional chemotherapy regimens. The present study investigated the use of vaccine of ovarian cancer stem cells (CSCs) to inhibit ovarian cancer growth. METHODS CD117(+)CD44(+)CS...

This paper has proposed a phase controlled and PWM power current source converter (CSC) for transmission line de-icing. The system consists of high-power thyristor-based commutated to contribute majority the dc de-icing low CSC provide part compensate order harmonic ac from TCR. Thus, grid can be highly sinusoidal. In avoid resonance caused by interaction between TCR CSC, virtual impedance cont...

The eeects of vibration on cathode strip chamber operation are analyzed. Gas gain variation and low frequency noise tolerances lead to a speciication of a maximum vibration amplitude for various frequencies. Possible resonant wire vibrations are described.

Chinese spelling check (CSC) is still an open problem today. To the best of our knowledge, language modeling is widely used in CSC because of its simplicity and fair predictive power, but most systems only use the conventional n-gram models. Our work in this paper continues this general line of research by further exploring different ways to glean extra semantic clues and Web resources to enhan...

Despite the efficacy of cardiac stem cells (CSCs) for treatment of cardiomyopathies, there are many limitations to stem cell therapies. CSC-derived exosomes (CSC-XOs) have been shown to be responsible for a large portion of the regenerative effects of CSCs. Using a mouse model of doxorubicin induced dilated cardiomyopathy, we study the effects of systemic delivery of human CSC-XOs in mice. Mice...

The predisposition of cigarette smokers for development of respiratory and oral bacterial infections is well documented. Cigarette smoke can also contribute to yeast infection. The aim of this study was to investigate the effect of cigarette smoke condensate (CSC) on C. albicans transition, chitin content, and response to environmental stress and to examine the interaction between CSC-pretreate...