This investigation has been aided by a grant from the Dr. Wallace C. and Clara A. Abbott Memorial Fund of The University of Chicago. Grateful acknowledgment is made to the following individuals for providing the gonadotrophic substances employed in the investigation. To Mr. Donald C. Wonder for Gonadin; to Dr. Oliver Kamm for Antuitrin-S; to Dr. J. A. Morrell for Prospermine; and to Dr. G. H. H...

Cryptorchidism is a known predisposing factor for the development of testicular tumors in adults. Age of patient at the time of treatment of undescended testes has some bearing on the risk of neoplasia. Testicular neoplasia at the time of primary surgery for cryptorchidism has been reported rarely in prepubertal period. We report a case where embryonal carcinoma was detected in a cryptorchid te...

A 36 year-old man after tests for assessing male infertility was diagnosed with primary infertility, bilateral cryptorchidism, nonobstructive azoospermia and discontinuous splenogonadal fusion. Carcinoma in situ was found in his left testicle, which was intraabdominal and associated with splenogonadal fusion. To our knowledge, this is the fourth case of splenogonadal fusion associated with test...

UNLABELLED The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demons...

Administration of human chorionic gonadotropin (HCG) to prepubertal Thoroughbred colts results in significant increases in serum testosterone concentrations. Colts with cryptorchid testicles have a reduced response in testosterone concentration compared to colts with descended testicles. Treatment with HCG facilitates descent of inguinally located testicles. Author’s address: Large Animal Medic...