Spine-venom gland and gonad of the scorpion fish Scorpaenopsis venosa was excised and extracted with Phosphate Buffer Saline. Crude protein was purified using DEAE cellulose anion exchange column chromatography. Protein content of the purified fractions of spine venom gland ranged from 0.053 to 0.076 mg.ml. Whereas, the protein content of the purified gonad extracts ranged from 0.056 to 0.076 m...

Toxins purified from the venom of spiders have high potential to be studied pharmacologically and biochemically. These biomolecules may have biotechnological and therapeutic applications. This study aimed to evaluate the protein content of Parawixia bistriata venom and functionally characterize its proteins that have potential for biotechnological applications. The crude venom showed no phospho...

Background Cancer is one of the major health problems worldwide. Hence, finding potent therapeutics from natural sources seems necessary. Snake venom of Vipera lebetina contains potential component with anticancer activities such as antiproliferation, migration, invasion, adhesion, and angiogenesis effect. Evaluation of cytotoxic and antiadhesive effect of V. lebetina venom on lung epithelial c...

Along with food and drug allergic reactions, a Hymenoptera insect Sting (Apoidea, Vespidae, Formicidae) is one of the most common causes of anaphylaxis worldwide. Diagnoses of Hymenoptera venom allergy (HVA) and specific immunotherapy (SIT) have been based on the use of crude venom extracts. However, the incidence of cross-reactivity and low levels of sensibility during diagnosis, as well as th...

A mixed toxoid consisting of HR1 and HR2 toxoids derived from Habu (Trimeresurus flavoviridis) venom was examined for immunogenicity in guinea pigs, rabbits, monkeys and human beings. The toxoid produced both anti-HR1 and anti-HR2 in various animals. The immunogenicity of the toxoid was superior to a crude toxoid in both guinea pigs and monkeys. Immunized monkeys showing circulating antitoxin p...

Despite comprising over half of the biodiversity living venomous vertebrates, fish venoms are comparatively understudied. Venom from lesser weever ( Echiichthys vipera syn. Trachinus ) has received only cursory attention despite containing one most potent venom toxins (trachinine). Literature records further complicated by early studies combining with that related greater draco ). The current s...

Consumption coagulopathy and hemorrhagic syndrome exacerbated by blood anticoagulability remain the most important causes of lethality associated with Bothrops snake envenomation. venom also engages platelet aggregation on injured endothelium via von Willebrand factor (vWF) interactions. Besides aggregation, some toxins may induce qualitative thrombopathy, which has been in part related to inhi...

Platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of Cerastes persicus fieldi and Echis carinatus were investigated. The partial fractionation was performed on a Sephadex G-100 column. Two fractions separated from Cerastes persicus fieldi showed anti platelet aggregation activity on ADP (200 μM)-induced platelet aggregation (ca 80% inhibi...

Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints as well as other organs in the body. Adjuvant-induced arthritis models in inbred rats serve as relevant models for RA, having many clinical similarities to this disease. Using honey bee venom as a treatment for Rheumatoid arthritis is an ancient therapy in various parts of the world. However scorpion ve...