Bacteriophage P4 DNA replication depends upon the phage-encoded a protein, which has DNA helicase and DNA primase activity and can specifically bind to the replication origin (ori) and to the cis replicating region (crr). The P4 Cnr protein functions as a negative regulator of P4 replication, and P4 does not replicate in cells that overexpress cnr. We searched for P4 mutants that suppressed thi...

In Spiroplasma citri, where homologous recombination is inefficient, specific gene targeting could only be achieved by using replicative, oriC plasmids. To improve the probability of selecting rare recombination events without fastidious, extensive passaging of the transformants, a new targeting vector was constructed, which was used to inactivate the crr gene encoding the IIA component of the ...

Replication initiation depends on origin recognition, helicase, and primase activities. In phage P4, a second DNA region, the cis replication region (crr), is also required for replication initiation. The multifunctional alpha protein of phage P4, which is essential for DNA replication, combines the three aforementioned activities on a single polypeptide chain. Protein domains responsible for t...

m i “ The meta-analysis reported in the three Guide to Community Preventive Services papers published in this issue of the American Journal of Preventive Medicine targets two basic prevention strategies— omprehensive risk reduction (CRR) and abstinence ducation—which have the common purpose of lowering dolescent sexual risk behavior. Meta-analyses were conucted for each strategy on key behavior...

The Constant-Ratio Rule (CRR), an empirical technique for analysis of confusion matrices, was developed for use in predicting intelligibility of speech syllables. This study investigated the validity of the rule when applied to the data from experiments on visual form perception. English letters and simple geometric figures were tachistoscopically presented in the center of a viewing field. Res...

A Dynamic Portfolio or Dynamic Asset Allocation is a strategy used to determine the proportion of a number of assets, chosen carefully, in order to achieve optimum performance of the portfolio. In this paper, the portfolio consists only Options traded in the financial market. One of the most famous models of option pricing is Binomial Cox-Ross-Rubinstein (CRR) Model. Using Fuzzy Binomial CRR pr...

We develop a pricing algorithm for US-style period-average reset options written on an underlying asset which evolves in a Cox-Ross-Rubinstein (CRR) framework. The averaging feature of such an option on the reset period makes the price valuation problem computationally unfeasible because the arithmetic average is not recombining on a CRR tree. To overcome this obstacle, we associate to each nod...

Extranodal natural killer/T cell lymphoma (ENKL) is a high invasive disease with poor prognosis. Since there is no consensus on standard chemotherapy, we developed an original chemotherapeutic DDGP (cisplatin, dexamethasone, gemcitabine, and pegaspargase) regimen. We retrospectively analyzed 80 patients who received DDGP chemotherapy. The primary end point was progression-free survival (PFS) an...

Background: To examine the Healthy Fitness Zone (pass/fail) criterionreferenced reliability (CRR) and equivalency (CRE) of the 1-mile run/walk (MRW) and Progressive Aerobic Cardiovascular Endurance Run (PACER) in adolescents (13 to 18 years). Methods: Seventy-six girls and 165 boys were randomly assigned to complete 2 trials of each test. Results: CRR for the boys on the MRW (Pa = 77%, κq = 0.5...

It is a common belief that the standard binomial algorithm of Cox-Ross-Rubinstein (CRR) cannot be used to deal with barrier options with multiple or time-varying boundaries. We propose an extension of the CRR model to evaluate options with exponential boundaries. The essence of the extended binomial model relies upon the construction of a binomial tree for the underlying asset price dynamics, c...