This study aims to develop a sustainable freight transportation network considering capacitated cross-docks for minimising the overall supply chain costs, including carbon emission cost. The problem is inspired by major retail company based in India, which would like expand its product portfolio new region. A mathematical model developed minimise total costs encompassing cost, pipeline and reta...

The establishment of neuronal connections during embryonic development requires the precise guidance and targeting of the neuronal growth cone, an expanded cellular structure at the leading tip of a growing axon. The growth cone contains sophisticated signaling systems that allow the rapid communication between guidance receptors and the actin cytoskeleton in generating directed motility. Previ...

Correct pathfinding by Drosophila photoreceptor axons requires recruitment of p21-activated kinase (Pak) to the membrane by the SH2-SH3 adaptor Dock. Here, we identify the guanine nucleotide exchange factor (GEF) Trio as another essential component in photoreceptor axon guidance. Regulated exchange activity of one of the two Trio GEF domains is critical for accurate pathfinding. This GEF domain...

Here, we show that postsynaptic p21-activated kinase (Pak) signaling diverges into two genetically separable pathways at the Drosophila neuromuscular junction. One pathway controls glutamate receptor abundance. Pak signaling within this pathway is specified by a required interaction with the adaptor protein Dreadlocks (Dock). We demonstrate that Dock is localized to the synapse via an Src homol...

The paper deals with a removable steel inner gate which was designed to separate two parts of a dry dock of about 70 m in width and 380 m in length. The gate allows for independent assembly of ship structures in the two separated parts of the dock. The fore part of the dock can be flooded while the after part is dry. The gate was designed by IDEK Company Ltd in 2011 and it was soon constructed ...

<p style='text-indent:20px;'>This study concerns the optimization of green supply chain network design under demand uncertainty. The issue uncertainty has been addressed using a scenario-based analysis approach. main contribution this research is to investigate cross-dock based formulation and metaheuristic algorithms. problem formulated as two-objective mathematical model with objectives...

Protein-peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein-peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins. While other docking algorithms require pre-defined localizat...

The Inland Transport Committee of the International Labour Organisation adopted at its Fourth Session (Nervi, Genoa, December 1951) a Resolution (No. 49) concerning the protection of dock workers against dust associated" with the handling of grain cargoes. At its 118th Session (Geneva, March 1952), the Governing Body decided to communicate the resolutions adopted on that occasion to Governments...

We present a bi-objective model for a green truck scheduling and routing problem at a cross-docking system. This model determines three key decisions at the cross dock: (1) defining a sequence and schedule of inbound trucks at the receiving door, (2) specifying a sequence and a schedule of outbound trucks at the shipping door, and (3) determining the routes of the outbound truck while serving c...

Tyrosine phosphorylation has been implicated in growth-cone guidance through genetic, biochemical, and pharmacological studies. Adapter proteins containing src homology 2 (SH2) domains and src homology 3 (SH3) domains provide a means of linking guidance signaling through phosphotyrosine to downstream effectors regulating growth-cone motility. The Drosophila adapter, Dreadlocks (Dock), the homol...