intestinal tuberculosis is an uncommon presentation of tuberculosis (tb) and has clinicopathological similarities with crohn's disease. in regions where tb is endemic clinicians must aware of this condition and fully evaluate their patients when crohn's disease is diagnosed. we recommend all pathologic specimens be evaluate effectively for tb.smear,culture and pcr for mycobacterium.tuberculosis...

BACKGROUND Two-thirds to three-fourths of patients with either refractory luminal or fistulizing Crohn disease respond to infliximab treatment. The ability or inability to respond seems to persist over time. Biological characteristics and/or genetic background can influence the response to treatment. The aim was to assess the value of C-reactive protein and TNF-alpha serum levels before treatme...

OBJECTIVE The purpose of this article is to assess the interobserver variability for scoring MRI features of Crohn disease activity and to correlate two MRI scoring systems to the Crohn disease endoscopic index of severity (CDEIS). MATERIALS AND METHODS Thirty-three consecutive patients with Crohn disease undergoing 3-T MRI examinations (T1-weighted with IV contrast medium administration and ...

NOD2 (nucleotide-binding oligomerization domain containing 2) functions as a pathogen sensor and is involved in development of Crohn disease, a form of inflammatory bowel disease. NOD2 functions in concert with the autophagy protein ATG16L1, which is also implicated in Crohn disease. Recently, we identified a novel protective role of ATG16L1 deficiency in uropathogenic Escherichia coli-induced ...

A polymerase chain reaction (PCR) assay targeted to the immunogenic protein MPB64 gene was used to detect members of the Mycobacterium tuberculosis complex, and an outward-primed PCR (OPPCR) designed on the IS6110 element allowed differentiation between Mycobacterium bovis and Mycobacterium tuberculosis. Additionally, the amplification of IS1110 and 16S ribosomal RNA sequences combined with a d...

We evaluated the safety and clinical outcome of autologous nonmyeloablative hematopoietic stem cell transplantation (HSCT) in patients with severe Crohn disease (CD) defined as a Crohn Disease Activity Index (CDAI) greater than 250, and/or Crohn Severity Index greater than 16 despite anti-tumor necrosis factor therapy. Stem cells were mobilized from the peripheral blood using cyclophosphamide (...

A doença de Crohn é uma inflamatória do trato gastrointestinal com etiologia multifatorial. Com base na gravidade da Doença e o efeito que ela ocasiona qualidade vida dos pacientes, esse trabalho visa discutir seus principais aspectos clínicos, envolvendo diagnóstico melhor manejo profissional. Realizou-se revisão literária coleta dados por meio bibliográfica para levantamentos secundários nos ...

Ulcerative colitis and Crohn disease are collectively called the inflammatory bowel diseases (IBDs) because of such similarities as a chronic remitting and relapsing course, their inflammatory nature, and their unknown causes. Nevertheless, these 2 disorders are clearly separated by distinct clinicopathologic features, including different locations within the gastrointestinal tract, diverse his...