Saffron (Crocus sativus) stigma tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. The study was a double-blind, placebo-controlled design consisting of a 1 week treatment of saffron tablets. Volunteers were divided into 3 groups of 10 each (5 males and 5 females). Group I received placebo; groups 2 and 3 received 200 and 400mg saffron tablets, respective...

growing interest to use natural preservatives and spices with antimicrobial effects and large amounts of floral bio-residues (92.6 g per 100 g) generated and wasted in the production of saffron spice guided this study  to evaluate  the opportunity to expand the uses of c. sativus flowers (petals and stamens), beyond the spice (dried stigmas). the antibacterial potential of total extracts and di...

in the way of finding economic and tolerable plant to the arid and semi-arid climatic conditions and prevent desertification in these areas, this study aims to assess agro-climatic suitability for producing saffron in east-azerbaijan province based on geographic information system (gis) spatial analysis technique. for this goal, several criteria including soil conditions, climatological indicat...

saffron, the dried red-orange stigmas of crocus sativus l, has been known as a flavoring agent, food coloring and traditional herbal medicine. pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. these components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

objective(s): in this study, the effects of chronic administration of crocin, an active constituent of saffron, on blood pressures of normotensive and desoxycorticosterone acetate (doca) - salt induced hypertensive rats, were investigated.   materials and methods: five week administration of three doses of crocin (50, 100 and 200 mg/kg/day) and spironolactone (50 mg/kg/day) in different groups ...

objective(s): gastric cancer is the first and second leading cause of cancer related death in iranian men and women, respectively. gastric cancer management is based on the surgery, radiotherapy and chemotherapy. in the present study, for the first time, the beneficial effect of saffron (crocus sativus l.) aqueous extract (sae) on the 1-methyl-3-nitro-1-nitrosoguanidine (mnng)-induced gastric c...

objective(s): in this study, the effects of crocin against subchronic toxicity of diazinon (dzn) on systolic blood pressure (sbp) and heart rate (hr) were evaluated in rats. materials and methods: rats were equally divided into 7 groups; control (corn oil), dzn (15 mg/kg), crocin (each group received 12.5, 25 or 50 mg/kg crocin plus dzn), vitamin e (200 iu/kg plus dzn) and crocin (50 mg/kg) tre...

the substances responsible for saffron’s characteristic quality are crocins, picrocrocin, and safranal. the drying process is critical to the saffron quality as measured by levels of secondary metabolites, crocin (color and anti-tumor properties), picrocrocin (taste), and safranal (aroma). four different dehydration methods were evaluated: iranian traditional method (room temperature); dehydrat...