Background: CPS-6 (EndoG) degrades chromosomal DNA during apoptosis. Results: Crystal structure of C. elegans CPS-6 was determined, and the DNA binding and cleavage mechanisms by CPS-6 were revealed. Conclusion: The DNase activity of CPS-6 is positively correlated with its pro-cell death activity. Significance: This study improves our general understanding of DNA hydrolysis by -metal finger ...

We present a new transformation of -terms into continuation-passing style (CPS). This transformation operates in one pass and is both compositional and !rst-order. Previous CPS transformations only enjoyed two out of the three properties of being !rst-order, one-pass, and compositional, but the new transformation enjoys all three properties. It is proved correct directly by structural induction...

Gough’s Creative Personality Scale (CPS) is a self-report personality inventory for creativity assessment. We investigated the undimensionality and the response process on the CPS from an ideal point (unfolding) perspective. The Graded Unfolding Model (GUM) was used to model binary responses and participants were 228 engineering students who completed a Greek version of the CPS. Results support...

Most isolates of Streptococcus pneumoniae are mixed populations of transparent (T) and opaque (O) colony phenotypes. Differences in the production of capsular polysaccharide (CPS) between O and T variants were accentuated by changes in the environmental concentration of oxygen. O variants demonstrated a 5.2- to 10.6-fold increase in amounts of CPS under anaerobic compared to atmospheric growth ...

In the context of the so-called fourth industrial revolution, cyber-physical systems (CPS) build the technological foundation for the increasing digitalisation of our world. Because guidelines to overcome challenges of building such systems (e.g. security concerns, missing know-how, and lack of standards) are scarce, researchers and practitioners alike have begun to analyse the role of the matu...

BACKGROUND Calcium polystyrene sulfonate (CPS) has long been used to treat hyperkalemia in patients with chronic kidney disease (CKD). However, its efficacy and safety profile have not been systematically explored. We investigated the long-term efficacy of oral CPS for treating mild hyperkalemia on an outpatient basis. METHODS We performed a retrospective analysis of ambulatory CKD patients w...

Local CPS conversion is a compiler transformation for improving the code generated for nested loops by a direct-style compiler. The transformation consists of a combination of CPS conversion and light-weight closure conversion, which allows the compiler to merge the environments of nested recursive functions. This merging, in turn, allows the backend to use a single machine-level procedure to i...

2D Platform and side scroller games such as Super Mario or Flappy Bird are very popular. Designing such games is an elaborate and creative process but a few simplified steps of interest include – the design of the primary character which usually includes simplified physics, the design of the level or map, the rules of the game and its challenges.The goal of this project was to explore if some a...

The CPS transformation makes all functions continuation-passing, uniformly. Not all functions, however, need continuations: they only do if their evaluation includes computational effects. In this paper we focus on control operations, in particular “call with current continuation” and “throw”. We characterize this involvement as a control effect and we present a selective CPS transformation tha...