Background. Overcoming radioresistance is an important problem in radiation oncology. Therefore, the development of new approaches to modeling radiosensitivity tumors cancer patients becomes relevant and important. Cyclooxygenase-2 (COX-2) inhibitors are agents for radiomodification various therapy schemes, use which slows down angiogenesis by suppressing activity COX-2 enzyme.
 Purpose. T...

Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme for prostanoid synthesis that is present in cortical pyramidal neurons and highly implicated in control of cerebral blood flow during neural activity. We examined the electron microscopic localization of COX-2 and neuronal nitric oxide synthase (nNOS), a functionally related enzyme, in the somatosensory cortex of rat brain to determine the rele...

Cyclooxygenases (COXs) are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids (PUFAs) to prostaglandins (PGs) and thromboxanes (TXs). Their main role is to catalyze the transformation of AA into the intermediate PGH2, which is the procursor of a variety of prostanoids (PTS) with diverse and potent biological actions. COXs have ...

Both nonsteroidal anti-inflammatory drugs, such as ibuprofen, and the prototypical selective cyclooxygenase (Cox)-2 inhibitors DuP-697 and NS-398 block the inhibition of Cox-1 by aspirin in vitro. However, clinical studies have shown that the Cox-2 selective drugs (or coxibs) rofecoxib and etoricoxib, at therapeutic doses, do not interfere with the antiplatelet effect of aspirin, in contrast to...

In adult mammalian kidney, cyclooxygenase-2 (COX-2) expression is found in a restricted subpopulation of cells. The two sites of renal COX-2 localization detected in all species to date are the macula densa (MD) and associated cortical thick ascending limb (cTALH) and medullary interstitial cells (MICs). Physiological regulation of COX-2 in these cellular compartments suggests functional roles ...

objective: pain control in dentistry especially endodontics is particularly important. endodontic pain following root canal therapy (rct) of vital teeth is closely correlated with inflammatory reactions. increased level of prostaglandins has been reported in acute inflammatory reactions. thus, cyclooxygenase-inhibiting drugs have a significant effect on reducing pain and inflammation. cox enzym...

PURPOSE Several studies have shown an overexpression of cyclooxygenase-2 (COX-2) and elevated levels of prostacyclin (PGI(2)) and thromboxane (TXA(2)) in colon cancer. In this report, we determined the distribution of inducible form of nitric oxide synthase (iNOS), PGI(2), and TXA(2) in cancerous and adjoining areas of specimens from human colon and breast cancer obtained during surgery. Additi...