Ion-pairing is reported to improve the lipophilicity and subsequently the transport rate of polar drugs across lipid membranes. Lipophilisation of ionic drugs with high aqueous solubilities by ion-pair formation with appropriate counter-ion have proven to be promising for several applications. The aim of this review is to present the usefulness of ion-pair for improving the poor bioavailability...

Single-ion detection has, for many years, been the domain of large devices such as the Geiger counter, and studies on interactions of ionized gasses with materials have been limited to large systems. To date, there have been no reports on single gaseous ion interaction with microelectronic devices, and single neutral atom detection techniques have shown only small, barely detectable responses. ...

Quantum-logic-based $${}^{27}\text {Al}^{+}$$ optical clock has been demonstrated in several schemes as there are different choices of the auxiliary ion species. In this paper, we present first detailed evaluation systematic shift and total uncertainty an sympathetically cooled by a $${}^{40}\text {Ca}^{+}$$ ion. The {Ca}^{+}- {}^{27}\text quantum logic estimated to be $$7.9\times 10^{-18}$$ , ...

Complexometric titrations rely on a drastic change of the pM value at the equivalence point with a water soluble chelator forming typically 1 : 1 complexes of high stability. The available chemical toolbox of suitable chelating compounds is unfortunately limited because many promising complexing agents are not water soluble. We introduce here a novel class of complexometric titration reagents, ...